发明授权
- 专利标题： Photodynamic viral deactivation with sapphyrins
- 专利标题（中）： 光动力病毒与莽草素的失活
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申请号： US454300申请日： 1989-12-21
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公开(公告)号： US5041078A公开(公告)日： 1991-08-20
- 发明人: J. Lester Matthews , Millard M. Judy , Joseph T. Newman , Frank Sogandares-Bernal , Jonathan L. Sessler , Anthony Harriman , Bhaskar G. Maiya
- 申请人： J. Lester Matthews , Millard M. Judy , Joseph T. Newman , Frank Sogandares-Bernal , Jonathan L. Sessler , Anthony Harriman , Bhaskar G. Maiya
- 申请人地址： TX Dallas TX Austin
- 专利权人： Baylor Research Foundation, a nonprofit corporation of the State of Texas,Board of Regents, The University of Texas System
- 当前专利权人： Baylor Research Foundation, a nonprofit corporation of the State of Texas,Board of Regents, The University of Texas System
- 当前专利权人地址： TX Dallas TX Austin
- 主分类号： A61K41/00
- IPC分类号： A61K41/00 ; A61L2/00 ; C07D487/22
摘要：
The present invention demonstrates a method of photodynamic inactivation of viruses having a membranous envelope, such as Herpes simplex type 1 and Human immunodeficiency type 1 viruses. The method uses substituted sapphyrin compounds to effect viral deactivation during radiation with light at or near the absorption wavelength of the sapphyrin compound. A highly reactive species selectively toxic to infectious agents is produced.One particular sapphyrin compound useful for the practice of the invention is 8,17-bis(carboxymethyl)-3,12,13,22-tetraethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 2). The most preferred sapphyrin sapphyrin compound for the practice of the invention is 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 1).The method is particularly suitable for inactivation of viruses in blood and blood products.
公开/授权文献
- US5794462A Disabling device 公开/授权日：1998-08-18
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