公开(公告)号：US5041078A

公开(公告)日：1991-08-20

申请号：US454300

申请日：1989-12-21

申请人： J. Lester Matthews ,  Millard M. Judy ,  Joseph T. Newman ,  Frank Sogandares-Bernal ,  Jonathan L. Sessler ,  Anthony Harriman ,  Bhaskar G. Maiya

发明人： J. Lester Matthews ,  Millard M. Judy ,  Joseph T. Newman ,  Frank Sogandares-Bernal ,  Jonathan L. Sessler ,  Anthony Harriman ,  Bhaskar G. Maiya

IPC分类号： A61K41/00 ,  A61L2/00 ,  C07D487/22

CPC分类号： A61K41/0038 ,  A61K41/0076 ,  A61K47/48069 ,  A61L2/0011 ,  A61L2/0088 ,  C07D487/22

摘要： The present invention demonstrates a method of photodynamic inactivation of viruses having a membranous envelope, such as Herpes simplex type 1 and Human immunodeficiency type 1 viruses. The method uses substituted sapphyrin compounds to effect viral deactivation during radiation with light at or near the absorption wavelength of the sapphyrin compound. A highly reactive species selectively toxic to infectious agents is produced.One particular sapphyrin compound useful for the practice of the invention is 8,17-bis(carboxymethyl)-3,12,13,22-tetraethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 2). The most preferred sapphyrin sapphyrin compound for the practice of the invention is 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 1).The method is particularly suitable for inactivation of viruses in blood and blood products.

摘要翻译： 本发明示出了具有膜包膜的病毒的光动力灭活方法，例如1型单纯疱疹病毒和1型人类免疫缺陷病毒。 该方法使用取代的莽草素化合物在辐射期间在卟啉化合物的吸收波长处或附近的光下实现病毒失活。 产生对感染性试剂有选择性毒性的高度活性的物质。 可用于实施本发明的一种特定的莽草素化合物是8,17-双（羧甲基）-3,12,13,22-四乙基-2,7,18,23-四甲基ap啶（Sapphyrin 2）。 用于实施本发明的最优选的鲑鱼卟吩化合物是3,8,12,13,17,22-六乙基-2,7,18,23-四甲基卟啉（Sapphyrin 1）。 该方法特别适合灭活血液和血液制品中的病毒。

公开(公告)号：US5120411A

公开(公告)日：1992-06-09

申请号：US454301

申请日：1989-12-21

申请人： Jonathan L. Sessler ,  Anthony Harriman ,  Bhaskar G. Maiya

发明人： Jonathan L. Sessler ,  Anthony Harriman ,  Bhaskar G. Maiya

IPC分类号： A61K41/00 ,  C01B13/02

CPC分类号： A61K41/0076 ,  C01B13/02

摘要： The present invention includes a method to produce singlet oxygen from molecular oxygen generated by reaction with a sapphyrin compound excited at an absorbing wavelength to form a triplet species. Specifically, the sapphyrin compound is an alkylated sapphyrin, most preferably diprotonated 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin. Generation of the triplet species may be accomplished in an organic solvent, of which the most preferable solvents are chloroform, methanol or acetonitrile.Also encompassed within the present invention is a method to selectively produce singlet oxygen in an aqueous environment. A sapphyrin compound is incorporated within a membranous vesicle, the vesicle is illuminated with exciting light and the resultant excited triplet state sapphyrin compound reacts with molecular oxygen to produce singlet oxygen. Singlet oxygen was not generated external to the vesicle where the sapphyrin compound is present in an aqueous medium.

摘要翻译： 本发明包括通过与以吸收波长激发的卟啉化合物反应产生的分子氧产生单线态以形成三线态的方法。 具体地说，札幌化合物是烷基化卟啉，最优选的是二质子化的3,8,12,13,17,22-六乙基-2,7,18,23-四甲基卟啉。 三重物质的生成可以在有机溶剂中完成，其中最优选的溶剂是氯仿，甲醇或乙腈。 在本发明中还包括在水性环境中选择性地产生单线态氧的方法。 将sap卟啉化合物掺入膜泡内，用激发光照射囊泡，得到的激发的三线态曙红化合物与分子氧反应产生单线态氧。 在水性介质中存在卟啉化合物的小泡外部不产生单线态氧。