发明授权
- 专利标题: Pharmaceutically active compounds
- 专利标题(中): 药物活性化合物
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申请号: US809474申请日: 1991-12-18
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公开(公告)号: US5272167A公开(公告)日: 1993-12-21
- 发明人: Viyyoor M. Girijavallabhan , Ashit K. Ganguly , Patrick A. Pinto , Richard W. Versace
- 申请人: Viyyoor M. Girijavallabhan , Ashit K. Ganguly , Patrick A. Pinto , Richard W. Versace
- 申请人地址: NJ Kenilworth
- 专利权人: Schering Corporation
- 当前专利权人: Schering Corporation
- 当前专利权人地址: NJ Kenilworth
- 主分类号: C07D213/30
- IPC分类号: C07D213/30 ; C07D213/69 ; C07D213/70 ; C07D233/54 ; C07D233/70 ; C07D233/90 ; C07D233/94 ; C07D235/06 ; C07D235/26 ; C07D235/28 ; C07D239/54 ; C07D257/04 ; C07D257/06 ; C07D277/36 ; C07D295/092 ; C07D307/20 ; C07D401/06 ; C07D405/06 ; C07D413/06 ; C07D413/12 ; C07D471/04 ; C07D473/00 ; C07D473/32 ; C07D473/34 ; C07D487/04 ; C07D493/04 ; C07D521/00 ; C07D401/12 ; A61K31/415
摘要:
Compounds of the formulaZ--X--Q--Y--Wpharmaceutically acceptable acid addition, basic addition salts or quaternary amine salts thereof, whereinZ is phenyl, substituted phenyl, wherein the substituents are independently one or more of halogen, lower alkylthio, loweralkylsulfonyl, lower alkoxy, oxazol-2-yl; imidazo-1-yl; lower alkyl substituted imidazo-1-yl; or tert-butyl;X is a bond, ##STR1## Q is lower alkane-diyl or 5, 6, or 7 carbon atoms optionally substituted by --OH; loweralkylnediyl of 6-8 carbon atoms; methylcyclohexylmethyl; tetrahydrofurandiyl; or (C.sub.1 -C.sub.2) lower alkane-diyl tetrahydrofurandiyl-C.sub.1 -C.sub.2 loweralkanediyl; wherein the tetrahydrofuran ring is substituted by 0-2 hydroxy groups;Y is a bond; andW is benzimidazol-1-yl or benzimidazol-2-yl are described. These compounds have antiviral activity, antiinflammatory activity and are PAF inhibitors.
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