Invention Grant
- Patent Title: Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
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Application No.: US844758Application Date: 1992-03-02
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Publication No.: US5429938APublication Date: 1995-07-04
- Inventor: H. David Humes
- Applicant: H. David Humes
- Applicant Address: MI Ann Arbor
- Assignee: University of Michigan
- Current Assignee: University of Michigan
- Current Assignee Address: MI Ann Arbor
- Main IPC: C12N15/09
- IPC: C12N15/09 ; A61F2/02 ; A61K31/20 ; A61K31/557 ; A61K31/57 ; A61K33/12 ; A61K33/24 ; A61K35/12 ; A61K38/22 ; A61K48/00 ; A61P13/02 ; A61P15/00 ; C12M3/06 ; C12N5/00 ; C12N5/02 ; C12N5/071 ; C12N5/074 ; C12N5/10 ; C12N15/63 ; C12N15/85 ; A61K38/18
Abstract:
Methods, including culture media conditions, which provide for isolation and purification of renal tubule stem cells and for in vitro kidney tubulogenesis are disclosed. The methods rely on culturing adult kidney cells in a culture media treated with combinations of transforming growth factor-.beta..sub.1, epidermal growth factor, and all-trans retinoic acid.
Public/Granted literature
- US5912666A Object-oriented global cursor tool Public/Granted day:1999-06-15
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