发明授权
- 专利标题： Thrombolytic peptide, production thereof, and thrombolytic agent
- 专利标题（中）： 溶血肽，其制备和溶栓剂
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申请号： US75545申请日： 1993-06-14
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公开(公告)号： US5475089A公开(公告)日： 1995-12-12
- 发明人: Osamu Matsuo , Masashi Sakai , Kisaku Shimura , Hiroshi Sansawa , Tsunekazu Watanabe , Tsuneo Matsumoto , Yoshiyuki Shishido , Shusuke Hashimoto , Teruo Yokokura , Masaharu Onoue , Tomoyuki Sako
- 申请人： Osamu Matsuo , Masashi Sakai , Kisaku Shimura , Hiroshi Sansawa , Tsunekazu Watanabe , Tsuneo Matsumoto , Yoshiyuki Shishido , Shusuke Hashimoto , Teruo Yokokura , Masaharu Onoue , Tomoyuki Sako
- 申请人地址： JPX Tokyo
- 专利权人： Kabushiki Kaisha Yakult Honsha
- 当前专利权人： Kabushiki Kaisha Yakult Honsha
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX2-411063 19901217
- 主分类号： A61K38/46
- IPC分类号： A61K38/46 ; C07K14/31 ; C12N9/52 ; A61K38/43 ; C07K14/00
摘要：
A thrombolytic peptide composed of 136 amino acids residues, which has little problems of antigenicity and is efficacious in only small doses as compared with staphylokinase (SAK). This peptide is obtained by cleaving amino acids or peptides which do not affect the activity of SAK by using a trypsin protease. In particular, SAK-11, which is obtained by cleaving a peptide composed of ten amino acid residues at the N-terminal of SAK, is superior to SAK in the fibrinolysis, plasminogen activation, and fibrin specificity.
公开/授权文献
- US6000356A Watercraft mooring apparatus 公开/授权日：1999-12-14