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公开(公告)号:US5475089A
公开(公告)日:1995-12-12
申请号:US75545
申请日:1993-06-14
申请人: Osamu Matsuo , Masashi Sakai , Kisaku Shimura , Hiroshi Sansawa , Tsunekazu Watanabe , Tsuneo Matsumoto , Yoshiyuki Shishido , Shusuke Hashimoto , Teruo Yokokura , Masaharu Onoue , Tomoyuki Sako
发明人: Osamu Matsuo , Masashi Sakai , Kisaku Shimura , Hiroshi Sansawa , Tsunekazu Watanabe , Tsuneo Matsumoto , Yoshiyuki Shishido , Shusuke Hashimoto , Teruo Yokokura , Masaharu Onoue , Tomoyuki Sako
CPC分类号: C07K14/31
摘要: A thrombolytic peptide composed of 136 amino acids residues, which has little problems of antigenicity and is efficacious in only small doses as compared with staphylokinase (SAK). This peptide is obtained by cleaving amino acids or peptides which do not affect the activity of SAK by using a trypsin protease. In particular, SAK-11, which is obtained by cleaving a peptide composed of ten amino acid residues at the N-terminal of SAK, is superior to SAK in the fibrinolysis, plasminogen activation, and fibrin specificity.
摘要翻译: PCT No.PCT / JP91 / 01722 Sec。 371日期:1993年6月14日 102(e)日期1993年6月14日PCT 1991年12月17日PCT公布。 出版物WO92 / 11356 日期:1992年7月9日。一种由136个氨基酸残基组成的血栓溶解肽,与葡萄球菌激酶(SAK)相比,其抗原性问题很小,仅有小剂量有效。 通过使用胰蛋白酶蛋白酶切割不影响SAK活性的氨基酸或肽来获得该肽。 特别地,通过在SAK的N末端切割由10个氨基酸残基构成的肽获得的SAK-11在纤维蛋白溶解,纤溶酶原激活和纤维蛋白特异性方面优于SAK。
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公开(公告)号:US20140038269A1
公开(公告)日:2014-02-06
申请号:US14111657
申请日:2012-04-12
申请人: Masakazu Ikeda , Hiroshi Ishikawa , Kisaku Shimura , Yuki Fukuda , Masahiko Ito
发明人: Masakazu Ikeda , Hiroshi Ishikawa , Kisaku Shimura , Yuki Fukuda , Masahiko Ito
IPC分类号: C12N1/16
CPC分类号: C12N1/16 , C12N1/04 , C12N9/2468 , C12N9/2471 , C12N9/96
摘要: An object of the present invention is to develop a means capable of maintaining the enzymatic activity of a microorganism even in a dry state. Provided is a method for producing a dry microbial cell powder maintaining an enzyme titer, characterized by comprising adding a carbohydrate to a liquid of microbial cells having an enzymatic activity and then drying the liquid. Also provided is a dry microbial cell powder obtained by the method.
摘要翻译: 本发明的目的是开发即使在干燥状态下也能维持微生物酶活性的方法。 本发明提供一种维持酶滴定度的干燥微生物细胞粉末的制造方法,其特征在于,向具有酶活性的微生物细胞的液体中添加碳水化合物,然后干燥所述液体。 还提供了通过该方法获得的干燥的微生物细胞粉末。
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公开(公告)号:US10465160B2
公开(公告)日:2019-11-05
申请号:US14111657
申请日:2012-04-12
申请人: Masakazu Ikeda , Hiroshi Ishikawa , Kisaku Shimura , Yuki Fukuda , Masahiko Ito
发明人: Masakazu Ikeda , Hiroshi Ishikawa , Kisaku Shimura , Yuki Fukuda , Masahiko Ito
摘要: An object of the present invention is to develop a means capable of maintaining the enzymatic activity of a microorganism even in a dry state. Provided is a method for producing a dry microbial cell powder maintaining an enzyme titer, characterized by comprising adding a carbohydrate to a liquid of microbial cells having an enzymatic activity and then drying the liquid. Also provided is a dry microbial cell powder obtained by the method.
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