摘要:
A thrombolytic peptide composed of 136 amino acids residues, which has little problems of antigenicity and is efficacious in only small doses as compared with staphylokinase (SAK). This peptide is obtained by cleaving amino acids or peptides which do not affect the activity of SAK by using a trypsin protease. In particular, SAK-11, which is obtained by cleaving a peptide composed of ten amino acid residues at the N-terminal of SAK, is superior to SAK in the fibrinolysis, plasminogen activation, and fibrin specificity.
摘要:
To provide a gene useful for imparting oxygen resistance to a microorganism and use of the gene.The oxygen-resistance-imparting gene encoding a protein selected from among the following proteins (a) to (c): (a) a protein having the amino acid sequence of SEQ ID NO: 2 or 6; (b) a protein which has an amino acid sequence equivalent to the amino acid sequence of (a), except that one to several amino acid residues are deleted, substituted, or added, and which exhibits oxygen-resistance-imparting activity; and (c) a protein which has an amino acid sequence having an identity of 85% or higher to the amino acid sequence of (a), and which exhibits oxygen-resistance-imparting activity.
摘要翻译:提供可用于赋予微生物耐氧性和使用该基因的基因。 编码选自以下蛋白质(a)〜(c)的蛋白质的耐氧性赋予基因:(a)具有SEQ ID NO:2或6的氨基酸序列的蛋白质; (b)具有与(a)的氨基酸序列相当的氨基酸序列的蛋白质,除了一至数个氨基酸残基被缺失,取代或添加,并且具有耐氧性赋予活性; 和(c)具有与(a)的氨基酸序列同一性为85%以上的氨基酸序列的蛋白质,其具有耐氧性赋予活性。
摘要:
Novel coliform bacillus useful for industrial production of staphylokinase, a fibrinolytic enzyme, and process for the production of staphylokinase using said microbe are provided. The novel microbe comprises a recombinant DNA, carrying genetic information for the production of staphylokinase, said genetic information being DNA derived from a temperate phage DNA of Staphylococcus aureus.
摘要:
The invention provides a gene encoding a protein selected from among the following proteins (a) to (c): (a) a protein having any of the amino acid sequences of SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, and 108; (b) a protein which has an amino acid sequence equivalent to any of the amino acid sequences of (a), except that one to several amino acid residues are deleted, substituted, or added, and which exhibits cytokine production regulatory activity; and (c) a protein which has an amino acid sequence having 90% or higher identity to any of the amino acid sequences of (a), and which exhibits cytokine production regulatory activity, as well as a gene useful for regulating cytokine production and use of the gene.
摘要翻译:本发明提供了编码选自以下蛋白质(a)〜(c)的蛋白质的基因:(a)具有SEQ ID NO:2,4,6,8,10,12的任意氨基酸序列的蛋白质 ,14,16,82,84,86,88,90,92,94,96,98,100,102,104,106及108; (b)具有与(a)的任何氨基酸序列相同的氨基酸序列的蛋白质,除了一至数个氨基酸残基被缺失,取代或添加,并且其表现出细胞因子产生调节活性; 和(c)具有与(a)的任何氨基酸序列具有90%或更高同一性并且表现出细胞因子产生调节活性的氨基酸序列的蛋白质,以及可用于调节细胞因子产生和使用的基因 的基因。
摘要:
An internetwork device comprises a receiving module, an inter-device packet transfer interface, an inter-device packet transfer controller, an address translation module, and a transmission module. The receiving module receives a packet from a first network. The inter-device packet transfer interface carries out inter-device packet transfer involving transfer of a packet to or from another internetwork device. The inter-device packet transfer controller controls the inter-device packet transfers such that multiple fragmented packets created from a same original packet are collected by the same internetwork device, the fragmented packets being packets created by dividing a single original packet into multiple parts. The address translation module translates between a local address used within a specific network and a global address used across multiple networks, for at least one of a source address and a destination address of a packet. The transmission module transmits an address-translated packet to a second network.
摘要:
A method for producing bacteria belonging to the genus Bifidobacterium having excellent viability even under various conditions with different environmental factors, novel bacteria belonging to the genus Bifidobacterium obtained by the method, and a method for detecting the bacteria are provided. By subculturing and storing bacteria belonging to the genus Bifidobacterium alternately in systems under conditions with different environmental factors, the bacteria belonging to the genus Bifidobacterium exhibiting excellent viability under all the conditions used for the alternate subculturing and storing can be produced.
摘要:
A method for producing bacteria belonging to the genus Bifidobacterium having excellent viability even under various conditions with different environmental factors, novel bacteria belonging to the genus Bifidobacterium obtained by the method, and a method for detecting the bacteria are provided. By subculturing and storing bacteria belonging to the genus Bifidobacterium alternately in systems under conditions with different environmental factors, the bacteria belonging to the genus Bifidobacterium exhibiting excellent viability under all the conditions used for the alternate subculturing and storing can be produced.
摘要:
An internetwork device comprises a receiving module, an inter-device packet transfer interface, an inter-device packet transfer controller, an address translation module, and a transmission module. The receiving module receives a packet from a first network. The inter-device packet transfer interface carries out inter-device packet transfer involving transfer of a packet to or from another internetwork device. The inter-device packet transfer controller controls the inter-device packet transfers such that multiple fragmented packets created from a same original packet are collected by the same internetwork device, the fragmented packets being packets created by dividing a single original packet into multiple parts. The address translation module translates between a local address used within a specific network and a global address used across multiple networks, for at least one of a source address and a destination address of a packet. The transmission module transmits an address-translated packet to a second network.
摘要:
The invention provides a gene encoding a protein selected from among the following proteins (a) to (c): (a) a protein having any of the amino acid sequences of SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, and 108; (b) a protein which has an amino acid sequence equivalent to any of the amino acid sequences of (a), except that one to several amino acid residues are deleted, substituted, or added, and which exhibits cytokine production regulatory activity; and (c) a protein which has an amino acid sequence having 90% or higher identity to any of the amino acid sequences of (a), and which exhibits cytokine production regulatory activity, as well as a gene useful for regulating cytokine production and use of the gene.
摘要翻译:本发明提供了编码选自以下蛋白质(a)〜(c)的蛋白质的基因:(a)具有SEQ ID NO:2,4,6,8,10,12的任意氨基酸序列的蛋白质 ,14,16,82,84,86,88,90,92,94,96,98,100,102,104,106及108; (b)具有与(a)的任何氨基酸序列相同的氨基酸序列的蛋白质,除了一至数个氨基酸残基被缺失,取代或添加,并且其表现出细胞因子产生调节活性; 和(c)具有与(a)的任何氨基酸序列具有90%或更高同一性并且表现出细胞因子产生调节活性的氨基酸序列的蛋白质,以及可用于调节细胞因子产生和使用的基因 的基因。
摘要:
Methods for transferring a foreign gene into a host chromosome by integrating the foreign gene into a vector by utilizing a lysogenic phage, for the purpose of deleting unnecessary genes derived from the vector, except for the foreign gene. One method comprises (a) preparing a vector with a lysogenic phage integration site (such as an attP site) arranged between a first partial sequence of the objective foreign gene to be transferred, but lacking one terminal region thereof and a second partial sequence of the gene, but lacking the other terminal region, the second partial sequence having an overlapping region with a portion of the first partial sequence; (b) integrating the vector obtained in step (a) into the host chromosome; and (c) screening from among the recombinants obtained in step (b) a recombinant from which unnecessary genes originating in the vector have been deleted owing to the homologous recombination mechanism functioning in the overlapping region between the first and second partial sequences.