发明授权
US5480786A Process for the biotechnological preparation of l-thienylalanines in
enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and
their use
失效
从2-羟基-3-噻吩基丙烯酸以对映异构体纯形式生物技术制备1-噻吩丙氨酸的方法及其用途
- 专利标题： Process for the biotechnological preparation of l-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and their use
- 专利标题（中）： 从2-羟基-3-噻吩基丙烯酸以对映异构体纯形式生物技术制备1-噻吩丙氨酸的方法及其用途
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申请号： US99352申请日： 1993-07-29
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公开(公告)号： US5480786A公开(公告)日： 1996-01-02
- 发明人: Gerhard Kretzschmar , Johannes Meiwes , Manfred Schudok , Peter Hammann , Ulrich Lerch , Susanne Grabley
- 申请人： Gerhard Kretzschmar , Johannes Meiwes , Manfred Schudok , Peter Hammann , Ulrich Lerch , Susanne Grabley
- 申请人地址： DEX Frankfurt am Main
- 专利权人： Hoechst Aktiengesellschaft
- 当前专利权人： Hoechst Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt am Main
- 优先权： DEX4225280.6 19920731
- 主分类号： C07D233/64
- IPC分类号： C07D233/64 ; C07D333/24 ; C07D333/28 ; C07D333/42 ; C07D409/06 ; C07K1/00 ; C12P13/04 ; C12P13/06 ; C12P17/00 ; C12R1/01 ; C12R1/19 ; C12N9/10
摘要：
L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.
公开/授权文献
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