发明授权
US5547949A Steroids with pregnane skeleton, pharmaceutical compositions containing
them
失效
具有孕烷骨架的类固醇,含有它们的药物组合物
- 专利标题: Steroids with pregnane skeleton, pharmaceutical compositions containing them
- 专利标题(中): 具有孕烷骨架的类固醇,含有它们的药物组合物
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申请号: US351448申请日: 1994-12-08
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公开(公告)号: US5547949A公开(公告)日: 1996-08-20
- 发明人: Sandor Maho , Zoltan Tuba , Aniko Gere , Pal Vittay , Bela Kiss , Eva Palosi , Laszlo Szporny , Erzsebet C. Francsicsne , Anna M. Boorne , Gabor Balogh , Sandor Gorog
- 申请人: Sandor Maho , Zoltan Tuba , Aniko Gere , Pal Vittay , Bela Kiss , Eva Palosi , Laszlo Szporny , Erzsebet C. Francsicsne , Anna M. Boorne , Gabor Balogh , Sandor Gorog
- 申请人地址: HUX Budapest
- 专利权人: Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人: Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人地址: HUX Budapest
- 优先权: HUX1910/92 19920609
- 主分类号: A61K31/57
- IPC分类号: A61K31/57 ; A61K31/58 ; A61P3/06 ; C07D239/42 ; C07D239/48 ; C07D239/50 ; C07D491/10 ; C07J20060101 ; C07J9/00 ; C07J43/00 ; A61K31/56
摘要:
Novel, therapeutically active 21-aminosteroids of formula (I) ##STR1## with pregnane skeleton, are disclosed wherein two of X, Y and Z are a nitrogen atom each and the third one is a methine group; R.sup.1 and R.sup.2 are independently from each other, a primary amino group bearing as substituent a branched-chain C.sub.4-8 alkyl -alkenyl or -alkynyl group, or a C.sub.4-10 cycloalkyl group comprising 1 to 3 ring(s) and being optionally substituted by at least one C.sub.1-3 alkyl group; or R.sup.1 and R.sup.2 are each a spiro-heterocyclic secondary amino group containing at most 10 carbon atoms and optionally at least one oxygen atom as additional heteroatom; or one of R.sup.1 and R.sup.2 is an unsubstituted heterocyclic secondary amino group containing 4 to 7 carbon atoms and the other one is an above-identified primary amino group, an above-identified spiro-heterocyclic secondary amino group, or a heterocyclic secondary amino group containing 4 to 7 carbon atoms and substituted by at least one C.sub.1-4 alkyl group; and n is 1 or 2, as well as their acid addition salts and pharmaceutical compositions containing these compounds.
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