发明授权
US5571510A Method for selective methionine starvation of malignant cells in mammals
失效
哺乳动物恶性细胞选择性甲硫氨酸饥饿的方法
- 专利标题： Method for selective methionine starvation of malignant cells in mammals
- 专利标题（中）： 哺乳动物恶性细胞选择性甲硫氨酸饥饿的方法
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申请号： US176413申请日： 1993-12-29
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公开(公告)号： US5571510A公开(公告)日： 1996-11-05
- 发明人: Tsutomu Nobori , Dennis A. Carson
- 申请人： Tsutomu Nobori , Dennis A. Carson
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K38/46 ; A61K38/51 ; A61K47/48 ; A61P35/00 ; C07H21/04 ; C12N9/88 ; C12N15/00 ; C12N15/60 ; C12Q1/48 ; C12Q1/527 ; C12Q1/68 ; C12R1/19 ; C12R1/40 ; G01N33/573
摘要：
An improved method for chemotherapy of mammalian malignant cells which have an absolute requirement for methionine but lack methylthioadenosine phosphorylase (MTAse). The method comprises detection of MTAse negative cells in a mammal, administration of methionine .gamma.-lyase in sufficient amounts to reduce the volume of MTAse negative cells in the mammal, and co-administration of methylthioadenosine in amounts sufficient to ensure the continued availability of methionine to the mammal's non-malignant cells. Means for detection of MTAse negative cells are provided. Means for production and use of recombinant chemotherapeutic agents are also provided.
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