发明授权
US5622832A Arachidonic acid releasing phospholipase A2 enzyme and methods of use
失效
花生四烯酸释放磷脂酶A2酶及使用方法
- 专利标题： Arachidonic acid releasing phospholipase A2 enzyme and methods of use
- 专利标题（中）： 花生四烯酸释放磷脂酶A2酶及使用方法
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申请号： US486628申请日： 1990-02-28
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公开(公告)号： US5622832A公开(公告)日： 1997-04-22
- 发明人: John L. Knopf , James Clark
- 申请人： John L. Knopf , James Clark
- 申请人地址： MA Cambridge
- 专利权人： Genetics Institute, Inc.
- 当前专利权人： Genetics Institute, Inc.
- 当前专利权人地址： MA Cambridge
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C12N9/20 ; C12N15/55 ; C12Q1/44
摘要：
The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
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