发明授权
- 专利标题： Tissue plasminogen activator
- 专利标题（中）： 组织纤溶酶原激活剂
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申请号： US412859申请日： 1995-03-29
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公开(公告)号： US5648250A公开(公告)日： 1997-07-15
- 发明人: Mineo Niwa , Yoshimasa Saito , Hitoshi Sasaki , Masako Hayashi , Jouji Notani , Masakazu Kobayashi
- 申请人： Mineo Niwa , Yoshimasa Saito , Hitoshi Sasaki , Masako Hayashi , Jouji Notani , Masakazu Kobayashi
- 申请人地址： JPX Osaka
- 专利权人： Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人： Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： GBX8718298 19870803; GBX8725052 19871026; GBX8726683 19871113
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/46 ; A61K38/48 ; A61P7/02 ; C07H21/04 ; C07K14/745 ; C12N1/20 ; C12N1/21 ; C12N5/10 ; C12N9/64 ; C12N9/72 ; C12N15/58 ; C12R1/19 ; C12R1/91 ; C12N15/70 ; A61K38/49
摘要：
The invention relates to a new tissue plasminogen activator which has strong activity for converting plasminogen into plasmin that degrades the fibrin network of blood clots to form soluble products and therefore is useful as a thrombolytic agent. The invention also relates to a DNA sequence encoding the amino acid sequence for the tissue plasminogen activator, to a process for producing the plasminogen activator, and to a pharmaceutical composition comprising the new tissue plasminogen activator.
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