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发明授权
US5648511A Method for making intermediates useful in the synthesis of retroviral protease inhibitors 失效
制备可用于合成逆转录病毒蛋白酶抑制剂的中间体的方法

Method for making intermediates useful in the synthesis of retroviral protease inhibitors
摘要：
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.
摘要（中）：

对于易于大规模制备基于羟基脲的手性HIV蛋白酶抑制剂的中间体描述了合成。 该方法包括由手性α氨基醛形成非对映选择性环氧化物或羟腈。

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