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    Method for preparation of tertiary phosphines via nickel-catalyzed cross coupling
    4.
    发明授权
    Method for preparation of tertiary phosphines via nickel-catalyzed cross coupling 失效
    通过镍催化交叉偶联制备叔膦的方法

    公开(公告)号：US5874628A

    公开(公告)日：1999-02-23

    申请号：US824309

    申请日：1997-03-26

    申请人： Scott A. Laneman ,  David J. Ager ,  Amihia Eisenstadt

    发明人： Scott A. Laneman ,  David J. Ager ,  Amihia Eisenstadt

    IPC分类号： B01J31/26 ,  C07B61/00 ,  C07F9/50

    CPC分类号： C07F9/5068

    摘要： The invention is an improved method for the preparation of tertiary phosphines by way of cross-coupling of aryl, alkenyl, cycloalkenyl or aralkyl halides or aryl, alkenyl, cycloalkenyl or aralkyl sulfonate esters with chlorophosphines in the presence of a catalyst and a reductant. The general reaction scheme is shown below: ##STR1## wherein R.sup.1 is aryl, alkenyl, cycloalkenyl or aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl, or CONR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen, alkyl, aryl or aralkyl; R.sup.2 and R.sup.3 are independently aryl, alkyl, aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl or CoNR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen, alkyl, aryl or aralkyl; and n is 2 where R.sup.1 is a difunctional moiety and 1 for any other R.sup.1 ; and X is Cl, Br, I, or OSO.sub.2 Y; wherein Y is alkyl, trihalomethyl, phenyl, halophenyl, or alkylphenyl.

    摘要翻译： 本发明是通过芳基，链烯基，环烯基或芳烷基卤化物或芳基，烯基，环烯基或芳烷基磺酸酯与氯膦在催化剂和还原剂存在下交叉偶联来制备叔膦的改进方法。 一般反应方案如下所示：其中R 1为芳基，烯基，环烯基或芳烷基，其中任何一个可被一个或多个下列基团取代：烷基，芳基，芳烷基，烷氧基，烷酰基，氯，氟， 烷氧基羰基，氰基，三氟甲基，环烷基或CONR 4 R 5，其中R 4和R 5独立地是氢，烷基，芳基或芳烷基; R 2和R 3独立地为芳基，烷基，芳烷基，其中任一个可以被一个或多个下列基团取代：烷基，芳基，芳烷基，烷氧基，烷酰基，氯，氟，烷氧基羰基，氰基，三氟甲基，环烷基或CoNR 4 R 5，其中R 4 和R 5独立地是氢，烷基，芳基或芳烷基; 并且n为2，其中R 1为双官能部分，1为任何其它R 1; X为Cl，Br，I或OSO 2 Y; 其中Y是烷基，三卤代甲基，苯基，卤代苯基或烷基苯基。

    Method for preparation of tertiary phosphines via nickel-catalyzed cross coupling
    7.
    发明授权
    Method for preparation of tertiary phosphines via nickel-catalyzed cross coupling 有权
    通过镍催化交叉偶联制备叔膦的方法

    公开(公告)号：US5902904A

    公开(公告)日：1999-05-11

    申请号：US138004

    申请日：1998-08-21

    申请人： Scott A. Laneman ,  David J. Ager ,  Amihia Eisenstadt

    发明人： Scott A. Laneman ,  David J. Ager ,  Amihia Eisenstadt

    IPC分类号： B01J31/26 ,  C07B61/00 ,  C07F9/50

    CPC分类号： C07F9/5068

    摘要： The invention is an improved method for the preparation of tertiary phosphines by way of cross-coupling of aryl, alkenyl, cycloalkenyl or aralkyl halides or aryl, alkenyl, cycloalkenyl or aralkyl sulfonate esters with chlorophosphines in the presence of a catalyst and a reductant. The general reaction scheme is shown below: ##STR1## wherein R.sup.1 is aryl, alkenyl, cycloalkenyl or aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl, or CONR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen, alkyl, aryl or aralkyl; R.sup.2 and R.sup.3 are independently aryl, alkyl, aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl or CONR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen, alkyl, aryl or aralkyl; and n is 2 where R.sup.1 is a difunctional moiety and 1 for any other R.sup.1 ; and X is Cl, Br, I, or OSO.sub.2 Y; wherein Y is alkyl, trihalomethyl, phenyl, halophenyl, or alkylphenyl.

    摘要翻译： 本发明是通过芳基，链烯基，环烯基或芳烷基卤化物或芳基，烯基，环烯基或芳烷基磺酸酯与氯膦在催化剂和还原剂存在下交叉偶联来制备叔膦的改进方法。 一般反应方案如下所示：其中R1是芳基，烯基，环烯基或芳烷基，其中任何一个可以被一个或多个下列基团取代：烷基，芳基，芳烷基，烷氧基，烷酰基，氯，氟，烷氧基羰基，氰基 ，三氟甲基，环烷基或CONR 4 R 5，其中R 4和R 5独立地是氢，烷基，芳基或芳烷基; R 2和R 3独立地是芳基，烷基，芳烷基，其中任何一个可以被一个或多个下列基团取代：烷基，芳基，芳烷基，烷氧基，烷酰基，氯，氟，烷氧基羰基，氰基，三氟甲基，环烷基或CONR 4 R 5，其中R 4 和R 5独立地是氢，烷基，芳基或芳烷基; 并且n为2，其中R 1为双官能部分，1为任何其它R 1; X为Cl，Br，I或OSO 2 Y; 其中Y是烷基，三卤代甲基，苯基，卤代苯基或烷基苯基。