发明授权
- 专利标题： Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
- 专利标题（中）： 可用于抑制G蛋白功能和治疗增殖性疾病的三环化合物
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申请号： US446265申请日： 1995-05-22
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公开(公告)号： US5672611A公开(公告)日： 1997-09-30
- 发明人: Ronald J. Doll , Alan K. Mallams , Adriano Afonso , Dinanath F. Rane , Randall R. Rossman , F. George Njoroge
- 申请人： Ronald J. Doll , Alan K. Mallams , Adriano Afonso , Dinanath F. Rane , Randall R. Rossman , F. George Njoroge
- 申请人地址： NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： NJ Kenilworth
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/4427 ; A61K31/4433 ; A61K31/445 ; A61K31/47 ; A61K31/473 ; A61K31/495 ; A61P35/00 ; A61P43/00 ; C07D211/32 ; C07D213/28 ; C07D221/16 ; C07D401/06 ; C07D401/12 ; C07D401/14 ; C07D409/12 ; C07D491/04 ; C07D491/044 ; C07D211/06
摘要：
Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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