发明授权
US5683867A Systematic evolution of ligands by exponential enrichment: blended SELEX
失效
配体通过指数富集系统演化：混合SELEX
- 专利标题： Systematic evolution of ligands by exponential enrichment: blended SELEX
- 专利标题（中）： 配体通过指数富集系统演化：混合SELEX
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申请号： US234997申请日： 1994-04-28
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公开(公告)号： US5683867A公开(公告)日： 1997-11-04
- 发明人: Greg Biesecker , Sumedha D. Jayasena , Larry Gold , Drew Smith , Gary P. Kirschenheuter
- 申请人： Greg Biesecker , Sumedha D. Jayasena , Larry Gold , Drew Smith , Gary P. Kirschenheuter
- 申请人地址： CO Boulder
- 专利权人： NeXstar Pharmaceuticals, Inc.
- 当前专利权人： NeXstar Pharmaceuticals, Inc.
- 当前专利权人地址： CO Boulder
- 主分类号： C07B61/00
- IPC分类号： C07B61/00 ; C07H19/06 ; C07H19/10 ; C07H21/00 ; C12N15/10 ; C12N15/115 ; C12Q1/68 ; G01N33/531 ; G01N33/532 ; G01N33/535 ; G01N33/569 ; G01N33/68 ; G01N33/76 ; C07H21/02 ; C07H21/04 ; C12P19/34
摘要：
A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl (SEQ ID NO:2) ketone. This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
公开/授权文献
- US4912909A Direct mail article with mailable reply card 公开/授权日：1990-04-03
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