- 专利标题: LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
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申请号: US469606申请日: 1995-06-06
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公开(公告)号: US5723492A公开(公告)日: 1998-03-03
- 发明人: Nizal Samuel Chandrakumar , Barbara Baosheng Chen , Michael Clare , Bipinchandra Nanubhai Desai , Stevan Wakefield Djuric , Stephen Hermann Docter , Alan Frank Gasiecki , Richard Arthur Haack , Chi-Dean Liang , Julie Marion Miyashiro , Thomas Dale Penning , Mark Andrew Russell , Stella Siu-tzyy Yu
- 申请人: Nizal Samuel Chandrakumar , Barbara Baosheng Chen , Michael Clare , Bipinchandra Nanubhai Desai , Stevan Wakefield Djuric , Stephen Hermann Docter , Alan Frank Gasiecki , Richard Arthur Haack , Chi-Dean Liang , Julie Marion Miyashiro , Thomas Dale Penning , Mark Andrew Russell , Stella Siu-tzyy Yu
- 申请人地址: IL Chicago
- 专利权人: G.D. Searle & Co.
- 当前专利权人: G.D. Searle & Co.
- 当前专利权人地址: IL Chicago
- 主分类号: C07D295/08
- IPC分类号: C07D295/08 ; A61K31/135 ; A61K31/138 ; A61K31/192 ; A61K31/195 ; A61K31/197 ; A61K31/215 ; A61K31/216 ; A61K31/34 ; A61K31/341 ; A61K31/343 ; A61K31/357 ; A61K31/36 ; A61K31/381 ; A61K31/40 ; A61K31/403 ; A61K31/404 ; A61K31/415 ; A61K31/4184 ; A61K31/435 ; A61K31/44 ; A61K31/4427 ; A61K31/443 ; A61K31/4433 ; A61K31/445 ; A61K31/4465 ; A61K31/4468 ; A61K31/4535 ; A61K31/454 ; A61K31/46 ; A61K31/495 ; A61K31/496 ; A61K31/535 ; A61K31/5355 ; A61K31/5375 ; A61K31/695 ; A61P29/00 ; A61P43/00 ; C07D207/14 ; C07D207/16 ; C07D209/12 ; C07D211/58 ; C07D211/62 ; C07D213/38 ; C07D215/12 ; C07D235/08 ; C07D277/24 ; C07D295/18 ; C07D307/42 ; C07D307/81 ; C07D307/85 ; C07D311/58 ; C07D317/54 ; C07D333/16 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D471/04 ; C07D473/08 ; C07D491/052 ; C07D491/107 ; A61K31/24
摘要:
The present invention provides compounds of the formula Ar.sup.1 --Q--Ar.sup.2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar.sup.1 and Ar.sup.2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD and asthma.
公开/授权文献
- US5077836A Headgear 公开/授权日:1992-01-07