Invention Grant
US5750394A Identification and use of antiviral compounds that inhibit interaction
of host cell proteins and viral proteins required for viral replication
失效
鉴定和使用抑制病毒复制所需的宿主细胞蛋白和病毒蛋白相互作用的抗病毒化合物
- Patent Title: Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication
- Patent Title (中): 鉴定和使用抑制病毒复制所需的宿主细胞蛋白和病毒蛋白相互作用的抗病毒化合物
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Application No.: US246583Application Date: 1994-05-20
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Publication No.: US5750394APublication Date: 1998-05-12
- Inventor: Peter Palese , Robert O'Neill
- Applicant: Peter Palese , Robert O'Neill
- Applicant Address: NY New York
- Assignee: The Mount Sinai Medical Center
- Current Assignee: The Mount Sinai Medical Center
- Current Assignee Address: NY New York
- Main IPC: G01N33/566
- IPC: G01N33/566 ; A61K38/00 ; A61P31/12 ; C07K14/47 ; C12N1/21 ; C12N15/09 ; C12P21/02 ; C12Q1/70 ; C12R1/19 ; G01N33/50 ; G01N33/569 ; C07H21/04 ; C12N5/10 ; C12N15/63
Abstract:
The present invention relates to the identification of host cell proteins that interact with viral proteins required for virus replication, and high throughput assays to identify compounds that interfere with the specific interaction between the viral and host cell protein. Interfering compounds that inhibit viral replication can be used therapeutically to treat viral infection. The invention is based, in part, on the discovery described herein of a novel interaction between the NP of influenza virus and a human host cell protein. The host cell protein, referred to herein as NPI-1, may be an accessory protein required for replication of influenza virus. Compounds that interfere with the binding of the host cell and viral proteins, and inhibit viral replication can be useful for treating viral infection in vivo.
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