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发明授权
US5776748A Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor 失效
在板上形成微型贴图的方法，用于细胞和其他生物材料的粘附，装置和用途

Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
摘要：
The disclosed invention is a device for adhering cells in a specific and predetermined position. The device comprises a plate defining a surface and a plurality of cytophilic islands that adhere cells which are isolated by cytophobic regions to which cells do not adhere and further is contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM). Further, the cytophobic regions are wide enough such that less than 10 percent of the cells adhered to the cytophilic islands are allowed to form bridges across the cytophobic regions and contact each other. The device is used in a method for culturing cells on a surface or in a medium and also for performing cytometry. Furthermore, the device is used in immobilization of cells at a surface and for controlling the shape of a cell.
摘要（中）：

所公开的发明是用于在特定和预定位置粘附电池的装置。 该装置包括限定表面的板和多个细胞亲和岛，所述细胞亲和岛附着细胞，所述细胞由细胞不粘附的细胞渗透区域分离，并且还与细胞色素岛连续。 岛或区域或两者可以由自组装单层（SAM）形成。 此外，细胞疏气区域足够宽，使得少于10％的细胞粘附到细胞色素岛被允许跨细胞疏漏区域形成桥接并彼此接触。 该装置用于在表面或培养基中培养细胞并用于进行细胞计数的方法。 此外，该装置用于在表面固定细胞并用于控制细胞的形状。

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