Invention Grant
US5801019A DNA encoding fused alpha-beta globin pseuodimer and production of
pseudotetrameric hemoglobin
失效
编码融合的α-β球蛋白pseuodimer的DNA和伪三聚体血红蛋白的产生
- Patent Title: DNA encoding fused alpha-beta globin pseuodimer and production of pseudotetrameric hemoglobin
- Patent Title (中): 编码融合的α-β球蛋白pseuodimer的DNA和伪三聚体血红蛋白的产生
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Application No.: US444939Application Date: 1995-05-19
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Publication No.: US5801019APublication Date: 1998-09-01
- Inventor: David C. Anderson , Antony James Mathews
- Applicant: David C. Anderson , Antony James Mathews
- Applicant Address: CO Boulder
- Assignee: Somatogen, Inc.
- Current Assignee: Somatogen, Inc.
- Current Assignee Address: CO Boulder
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/00 ; A61K47/48 ; A61P7/08 ; C07K20060101 ; C07K1/113 ; C07K14/805 ; C12N15/00 ; C12N15/09 ; C12N15/12 ; C12N15/81 ; C12P21/02 ; C12R1/19 ; C12R1/91 ; C12P21/06 ; C07H17/00
Abstract:
The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained.
Public/Granted literature
- US4495510A Improved superconductor/semiconductor junction structures Public/Granted day:1985-01-22
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