发明授权
- 专利标题： Heterocyclic acyldipeptides, processes for the preparation thereof and pharmaceutical compositions containing the same
- 专利标题（中）： 杂环酰基二肽，其制备方法和含有它们的药物组合物
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申请号： US537782申请日： 1996-01-04
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公开(公告)号： US5824652A公开(公告)日： 1998-10-20
- 发明人: Danijel Kikelj , Elizabeta Suhadolc , Alenka Rutar , Slavko Pecar , Alesa Puncuh , Uros Urleb , Vesna Leskovsek , Gasper Marc , Marija Sollner , Ales Krbavcic , Gregor Sersa , Srdjan Novakovic , Lucka Povsic , Anton Stalc
- 申请人： Danijel Kikelj , Elizabeta Suhadolc , Alenka Rutar , Slavko Pecar , Alesa Puncuh , Uros Urleb , Vesna Leskovsek , Gasper Marc , Marija Sollner , Ales Krbavcic , Gregor Sersa , Srdjan Novakovic , Lucka Povsic , Anton Stalc
- 申请人地址： SIX Ljubljana SIX Ljubljana
- 专利权人： Univerza v Ljubljani, Fakulteta za naravoslovje in technologijo, Oddelek za farmacijo,LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.
- 当前专利权人： Univerza v Ljubljani, Fakulteta za naravoslovje in technologijo, Oddelek za farmacijo,LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.
- 当前专利权人地址： SIX Ljubljana SIX Ljubljana
- 优先权： SIXP-9300212 19930422
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P35/00 ; A61P37/04 ; C07D265/36 ; C07D279/16 ; C07K5/06 ; C07K5/062 ; C07D471/02
摘要：
Heterocyclic acyldipeptides of the formula I ##STR1## wherein Z represents an oxygen or sulphur atom or a --CH.sub.2 -group; R.sub.1, R.sub.2 and R.sub.3 individually represent hydrogen or certain organic groups; R.sub.4 and R.sub.5, which are identical or different, represent an OR.sub.6 or NHR.sub.6 group, wherein R.sub.6 is hydrogen or certain organic groups; Y represents a --CH.sub.2 --, .dbd.CH-- or .dbd.N-- group; A represents a --(CH.sub.2).sub.3 -- group when Y is --CH.sub.2 --, the two rings being transcondensed, or a ##STR2## wherein R.sub.7 represents H, F, Br, Cl, nitro, or certain organic groups when Y is .dbd.CH-- or .dbd.N--; and their pharmaceutically acceptable salts are provided. These heterocyclic acyldipeptides and their salts are useful as active compounds in medicaments having immunostimulatory and antitumor activity.
公开/授权文献
- US4976042A Sine plate adjustable tension clamp 公开/授权日：1990-12-11
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