发明授权
US5834212A Anti-human stromelysin monoclonal antibody and method for diagnosis of
rheumatoid arthritis by enzyme immunoassay
失效
抗人类溶基质蛋白单克隆抗体和通过酶免疫测定法诊断类风湿性关节炎的方法
- 专利标题： Anti-human stromelysin monoclonal antibody and method for diagnosis of rheumatoid arthritis by enzyme immunoassay
- 专利标题（中）： 抗人类溶基质蛋白单克隆抗体和通过酶免疫测定法诊断类风湿性关节炎的方法
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申请号： US417847申请日： 1995-04-06
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公开(公告)号： US5834212A公开(公告)日： 1998-11-10
- 发明人: Yasunori Okada , Masayoshi Shinmei , Taro Hayakawa , Kazushi Iwata , Yumi Korin , Shuji Kodama , Shinichi Yoshida
- 申请人： Yasunori Okada , Masayoshi Shinmei , Taro Hayakawa , Kazushi Iwata , Yumi Korin , Shuji Kodama , Shinichi Yoshida
- 专利权人： Fuji Yakuhin Kogyo Kk
- 当前专利权人： Fuji Yakuhin Kogyo Kk
- 优先权： JPX3-078155 19910121; WOXPCT/JP92/00041 19920121
- 主分类号： C12N5/10
- IPC分类号： C12N5/10 ; C07K16/00 ; C07K16/40 ; C07K19/00 ; C12N5/20 ; C12N9/64 ; C12N15/02 ; C12P21/08 ; C12R1/91 ; G01N33/564 ; G01N33/573 ; G01N33/577 ; G01N33/543
摘要：
Anti-human stromelysin monoclonal antibodies reactive with latent and active forms of stromelysin without discrimination between the two, each being immunoreactive with only one of the antigenic determinants of human stromelysin, are provided. The use of a combination of two such monoclonal antibodies which specifically react with different antigenic determinants of human stromelysin renders it possible to accurately determine the amount of human stromelysin in human body fluids, and thus to carry out the diagnosis of rheumatoid arthritis. There are thus provided said monoclonal antibodies per se, a sandwich enzyme immunoassay for the determination of the amount of human stromelysin in human body fluid samples using a combination of two such monoclonal antibodies, and a method for the diagnosis of rheumatoid arthritis using said immunoassay.
公开/授权文献
- US06119980A Seat 公开/授权日：2000-09-19
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