Invention Grant
- Patent Title: Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
- Patent Title (中): 水解初级酰胺的催化抗体和引发此类抗体的方法
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Application No.: US362470Application Date: 1996-05-04
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Publication No.: US5900237APublication Date: 1999-05-04
- Inventor: Andrew D. Napper , Richard C. Titmas , Mark T. Martin , Wonpyo Hong
- Applicant: Andrew D. Napper , Richard C. Titmas , Mark T. Martin , Wonpyo Hong
- Applicant Address: MD Gaithersburg
- Assignee: IGEN International, Inc.
- Current Assignee: IGEN International, Inc.
- Current Assignee Address: MD Gaithersburg
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/43 ; A61P37/02 ; C07C229/46 ; C07C229/48 ; C07C235/74 ; C07C271/24 ; C07C311/06 ; C07C311/19 ; C07C317/44 ; C07D205/085 ; C07D207/40 ; C07D207/404 ; C07F9/24 ; C07F9/30 ; C07F9/32 ; C07F9/40 ; C07F9/48 ; C07F9/553 ; C07F9/6509 ; C07F9/6571 ; C07H15/252 ; C07H19/04 ; C07K7/08 ; C07K14/55 ; C07K14/585 ; C07K14/595 ; C07K16/00 ; C07K16/10 ; C07K16/26 ; C07K16/42 ; C07K16/44 ; C07K16/46 ; C12N9/00 ; C12P1/00 ; C12P13/22 ; C12P17/10 ; C12P19/34 ; C12P41/00 ; C12Q1/25 ; G01N33/50 ; G01N33/531 ; G01N33/535 ; G01N33/542 ; G01N33/577 ; A61K39/395
Abstract:
Described and claimed are compounds of formula (I) wherein Y is a polypeptide, R.sub.1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C.sub.1-21 alkyl, alkene, or alkyne group, R.sub.2 is a side chain of a naturally occurring amino acid, and X is (a), (b), (c). Such compounds are useful as haptens and immunogens for the elicitation of antibodies which catalytically enhance the rate of formation or hydrolysis of primary amide bonds. Also described and claimed are methods employing the compounds and antibodies.
Public/Granted literature
- US06117615A Method for mounting multiple printing elements onto a cylindrical element Public/Granted day:2000-09-12
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