发明授权
- 专利标题: Thioether-containing metal chelating compounds
- 专利标题(中): 含硫醚的金属螯合化合物
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申请号: US888398申请日: 1997-07-07
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公开(公告)号: US5932707A公开(公告)日: 1999-08-03
- 发明人: Colin Mill Archer , Gary Robert Bower , Harjit Kaur Gill , Anthony Leonard Mark Riley , Anthony Eamon Storey , Lewis Reuben Canning , David Vaughan Griffiths
- 申请人: Colin Mill Archer , Gary Robert Bower , Harjit Kaur Gill , Anthony Leonard Mark Riley , Anthony Eamon Storey , Lewis Reuben Canning , David Vaughan Griffiths
- 申请人地址: GBX
- 专利权人: Nycomed Amersham plc
- 当前专利权人: Nycomed Amersham plc
- 当前专利权人地址: GBX
- 优先权: EPX93302634 19930402
- 主分类号: C07D249/00
- IPC分类号: C07D249/00 ; A61K47/48 ; A61K51/00 ; A61K51/04 ; C07B59/00 ; C07C323/40 ; C07C323/60 ; C07C327/00 ; C07D233/28 ; C07D233/91 ; C07D309/08 ; C07D401/06 ; C07D405/12 ; C07F5/00 ; C07F13/00 ; C07K5/06 ; C07K5/062 ; C07K5/083 ; C07C319/00 ; C07C321/00
摘要:
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have the formula (a) and (b), where A, A'=--SZ or Y, B=O or S, Y=(c), Z=H or a thiol protecting group, m=2 or 3, n=2 or 3, q=0 or 1, R=H or unsubstituted or substituted hydrocarbon and pharmaceutically acceptable salts, provided that at least one CR.sub.2 group represents CO and forms, together with an adjacent N atom; a --CONR-- amide group. ##STR1##
公开/授权文献
- US5213452A Router type cutter 公开/授权日:1993-05-25