发明授权
US5962253A Oxidative decarboxylation of peptides catalyzed by flavoprotein EpiD
失效
由黄素蛋白EpiD催化的肽的氧化脱羧
- 专利标题： Oxidative decarboxylation of peptides catalyzed by flavoprotein EpiD
- 专利标题（中）： 由黄素蛋白EpiD催化的肽的氧化脱羧
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申请号： US645193申请日： 1996-05-13
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公开(公告)号： US5962253A公开(公告)日： 1999-10-05
- 发明人: Thomas Kupke , Friedrich Gotz , Christoph Kempter , Gunther Jung
- 申请人： Thomas Kupke , Friedrich Gotz , Christoph Kempter , Gunther Jung
- 申请人地址： DEX Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DEX Ingelheim am Rhein
- 主分类号： C07K14/31
- IPC分类号： C07K14/31 ; C12N9/88 ; C12P21/04 ; C12P21/06 ; C12P33/20 ; C12N1/20 ; C12N9/04
摘要：
A method is described for oxidatively decarboxylating a peptide, comprising combining a peptide with EpiD, wherein the peptide comprises at its carboxy terminus the amino acid sequence X.sub.1 X.sub.2 X.sub.3 X.sub.4 X.sub.5 X.sub.6 C, wherein X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are any one of the twenty common amino acids, X.sub.5 is Tyr, Val, Met, Leu, Ile, Phe or Trp, and X.sub.6 is Cys, Ala, Ser, Val, or Thr, whereby the oxidative decarboxylation of the peptide occurs.
公开/授权文献
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