发明授权
US5968962A Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
失效
具有C-C键与4-8元杂环的苯基恶唑烷酮
- 专利标题： Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
- 专利标题（中）： 具有C-C键与4-8元杂环的苯基恶唑烷酮
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申请号： US696313申请日： 1996-08-13
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公开(公告)号： US5968962A公开(公告)日： 1999-10-19
- 发明人: Richard C. Thomas , Toni-Jo Poel , Michael R. Barbachyn
- 申请人： Richard C. Thomas , Toni-Jo Poel , Michael R. Barbachyn
- 申请人地址： MI Kalamazoo
- 专利权人： Pharmacia & Upjohn Company
- 当前专利权人： Pharmacia & Upjohn Company
- 当前专利权人地址： MI Kalamazoo
- 主分类号： C07D413/10
- IPC分类号： C07D413/10 ; A61K31/00 ; A61K31/42 ; A61K31/422 ; A61K31/425 ; A61K31/435 ; A61K31/4439 ; A61K31/445 ; A61K31/4462 ; A61K31/4465 ; A61K31/4523 ; A61K31/454 ; A61K31/495 ; A61K31/55 ; A61P31/00 ; A61P31/04 ; C07D205/04 ; C07D223/02 ; C07D225/02 ; C07D263/20 ; C07D277/14 ; C07D295/00 ; C07D413/02 ; C07D413/14 ; C07D417/14 ; C07D413/04
摘要：
A compound of the formula (I): ##STR1## or pharmaceutical acceptable salts thereof wherein X is NR.sub.1, S(O).sub.g, or O; R.sub.1 is H, C.sub.1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R.sub.1 is --(CH.sub.2).sub.h -- aryl, --COR.sub.1--1, --COOR.sub.1-2, --CO--(CH.sub.2).sub.h --COR.sub.1--1, C.sub.1-6 alkyl sulfonyl, --SO.sub.2 --(CH.sub.2).sub.h --aryl, or --(CO).sub.i --Het; R.sub.2 is H, C.sub.1-6 alkyl, --(CH.sub.2).sub.h --aryl, or halo; R.sub.3 and R.sub.4 are the same or different and are H or halo; R.sub.5 is H, C.sub.1-12 alkyl optionally substituted with one or more halo, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy. The compounds are useful antimicrobial agents.