发明授权
US06063569A Methods for automated synthesis of PNA-DNA chimeras and compositions
thereof
失效
自动合成PNA-DNA嵌合体的方法及其组合物
- 专利标题： Methods for automated synthesis of PNA-DNA chimeras and compositions thereof
- 专利标题（中）： 自动合成PNA-DNA嵌合体的方法及其组合物
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申请号： US910552申请日： 1997-08-11
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公开(公告)号： US06063569A公开(公告)日： 2000-05-16
- 发明人: Brian D. Gildea , James M. Coull
- 申请人： Brian D. Gildea , James M. Coull
- 申请人地址： MA Framingham
- 专利权人： PerSeptive Biosystems, Inc.
- 当前专利权人： PerSeptive Biosystems, Inc.
- 当前专利权人地址： MA Framingham
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/712 ; A61K48/00 ; C07C271/20 ; C07D239/46 ; C07D239/47 ; C07D239/54 ; C07D473/18 ; C07D473/32 ; C07D473/34 ; C07D473/40 ; C07H21/00 ; C07H21/04 ; C07K14/00 ; C12Q1/68 ; C07H19/00 ; C07H21/02
摘要：
A method is disclosed for the preparation of novel PNA synthons compatible with DNA synthetic reagents and instrumentation. Accordingly, the PNA synthons of this invention are particularly suitable for the preparation of PNA-DNA chimeras, among other oligomers. The PNA synthons are designed to have a protecting group strategy which is orthogonal and allows removal of the protecting groups under mild conditions. Generally, an acid labile protected backbone is coupled to a nucleobase side chain moiety to form the PNA synthon. A novel method for synthesizing the acid labile protected backbone also is described. In addition, novel compositions of matter are disclosed.
公开/授权文献
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