- 专利标题： Substituted benzopyran analogs for the treatment of inflammation
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申请号： US175584申请日： 1998-10-20
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公开(公告)号： US6077850A公开(公告)日： 2000-06-20
- 发明人: Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J. Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
- 申请人： Jeffery S Carter , Mark G Obukowicz , Balekudru Devadas , John J Talley , David L Brown , Matthew J Graneto , Stephen R Bertenshaw , Donald J Rogier, Jr. , Srinivasan Raj Nagarajan , Cathleen E Hanau , Susan J. Hartmann , Cindy L Ludwig , Suzanne Metz , Donald E Korte
- 申请人地址： IL Skokie
- 专利权人： G.D. Searle & Co.
- 当前专利权人： G.D. Searle & Co.
- 当前专利权人地址： IL Skokie
- 主分类号： C07D335/06
- IPC分类号： C07D335/06 ; A61K20060101 ; A61K31/35 ; A61K31/352 ; A61K31/381 ; A61K31/382 ; A61K31/4184 ; A61K31/443 ; A61K31/4433 ; A61K31/453 ; A61K31/47 ; A61K31/5377 ; A61P19/02 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07D20060101 ; C07D215/54 ; C07D221/00 ; C07D307/00 ; C07D311/00 ; C07D311/12 ; C07D311/22 ; C07D311/38 ; C07D311/58 ; C07D311/92 ; C07D317/00 ; C07D401/12 ; C07D405/04 ; C07D405/12 ; C07D407/04 ; C07D407/12 ; C07D409/04 ; C07D413/12 ; C07D471/04 ; C07D491/04 ; C07D491/052 ; C07D493/04 ; A61K31/44 ; A61K31/495 ; C07D215/16 ; C07D221/06
摘要：
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.
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