发明授权
- 专利标题： Stabilization of lipid:DNA formulations during nebulization
- 专利标题（中）： 脂质稳定：喷雾期间的DNA制剂
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申请号： US227648申请日： 1999-01-08
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公开(公告)号： US6106859A公开(公告)日： 2000-08-22
- 发明人: Charles L. Densmore, Jr. , J. Vernon Knight , J. Clifford Waldrep , Berma M. Kinsey
- 申请人： Charles L. Densmore, Jr. , J. Vernon Knight , J. Clifford Waldrep , Berma M. Kinsey
- 专利权人： Densmore, Jr.; Charles L.,Knight; J. Vernon,Waldrep; J. Clifford,Kinsey; Berma M.
- 当前专利权人： Densmore, Jr.; Charles L.,Knight; J. Vernon,Waldrep; J. Clifford,Kinsey; Berma M.
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K9/00 ; A61K9/12 ; A61K9/127 ; A61K31/711 ; A61K47/24 ; A61K47/28 ; A61K48/00 ; C12N5/00 ; C12N5/10 ; C12N15/00 ; C12N15/88 ; A61K51/00
摘要：
The present invention provides a liposomal aerosol composition, comprising a pharmaceutical compound, a cationic lipid, (c) a neutral co-lipid; and (d) tryptone. Also provided is a nebulized cationic lipid:DNA suspension useful for lipid-DNA transfections, wherein said cationic lipid is bis(guanidinium)-tren-cholesterol.
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