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    Aerosol drug inhibition of lung metastases
    6.
    发明授权
    Aerosol drug inhibition of lung metastases 失效
    气雾剂药物抑制肺转移

    公开(公告)号：US07288243B2

    公开(公告)日：2007-10-30

    申请号：US10439773

    申请日：2003-05-16

    申请人： J. Vernon Knight ,  J. Clifford Waldrep ,  Nadezhda Koshkina

    发明人： J. Vernon Knight ,  J. Clifford Waldrep ,  Nadezhda Koshkina

    IPC分类号： A61K47/00 ,  A61K47/30

    CPC分类号： A61K9/0078 ,  A61K9/127 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/7048 ,  A61K38/13 ,  A61K2300/00

    摘要： The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering a dose of a lipid-drug enhancer liposomal complex and, in sequence, administering a dose of a lipid-anticancer drug liposomal complex. Furthermore, the lipid-drug enhancer liposomal complex may be administered in a continuing dose with the lipid-anticancer drug liposomal complex whereby both liposomal complexes are mixed in the nebulizer. Methods of inhibiting growth of lung metastases in an individual by the sequential administration via aerosolization of a dilauroylphosphatidylcholine-cyclosporin A liposomal complex and a dilauroylphosphatidylcholine-paclitaxel liposomal complex are also provided.

    摘要翻译： 本发明提供一种抑制个体肺转移的生长的方法，其包括施用剂量的脂质 - 药物增强剂脂质体复合物的步骤，并且依次施用剂量的脂质 - 抗癌药物脂质体复合物。 此外，脂质 - 增强剂脂质体复合物可以与脂质 - 抗癌药物脂质体复合物持续给药，由此两个脂质体复合物都混合在喷雾器中。 还提供了通过二月桂酰磷脂酰胆碱 - 环孢菌素A脂质体复合物和二月桂酰磷脂酰胆碱 - 紫杉醇脂质体复合物的雾化顺序施用来抑制个体肺转移的生长的方法。

    Composition for treating cancer via liposomal aerosol formulation containing taxol
    9.
    发明授权
    Composition for treating cancer via liposomal aerosol formulation containing taxol 失效
    通过含有紫杉醇的脂质体气雾剂制剂治疗癌症的组合物

    公开(公告)号：US06346233B1

    公开(公告)日：2002-02-12

    申请号：US09617623

    申请日：2000-07-17

    申请人： J. Vernon Knight ,  J Clifford Waldrep ,  Nadezhda Koshkina ,  Brian Gilbert

    发明人： J. Vernon Knight ,  J Clifford Waldrep ,  Nadezhda Koshkina ,  Brian Gilbert

    IPC分类号： A61K912

    CPC分类号： A61K9/0078 ,  A61K9/127 ,  A61K31/03 ,  A61K31/175 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/52 ,  A61K31/7048 ,  A61K38/21 ,  Y10S514/938

    摘要： The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.

    摘要翻译： 本发明的小颗粒脂质体或脂质复合物气溶胶化合物和治疗方法涉及掺入脂质体或其它脂质复合物中的脂质或水溶性抗癌药物。 脂质体和复合物在水分散体中从喷雾器到个体的呼吸道施用。 可以使用各种抗癌药，包括20-S-喜树碱，9-硝基喜树碱，9-氨基喜树碱，10,11-亚甲二氧基喜树碱和紫杉醇或其衍生物。 通过吸入给药这些药物比肌肉内给药或口服给药提供更快更有效的抗癌药物吸收。

    SMALL PARTICLE LIPOSOME AEROSOLS FOR DELIVERY OF ANTI-CANCER DRUGS
    10.
    发明申请
    SMALL PARTICLE LIPOSOME AEROSOLS FOR DELIVERY OF ANTI-CANCER DRUGS 审中-公开
    用于递送抗癌药物的小颗粒脂蛋白激酶

    公开(公告)号：US20080248096A1

    公开(公告)日：2008-10-09

    申请号：US12020378

    申请日：2008-01-25

    申请人： Claire F. Verschraegen ,  J. Vernon Knight ,  Nadezhda Koshkina ,  Brian Gilbert

    发明人： Claire F. Verschraegen ,  J. Vernon Knight ,  Nadezhda Koshkina ,  Brian Gilbert

    IPC分类号： A61K9/127 ,  A61K31/4375 ,  A61P35/00

    CPC分类号： A61K9/0078 ,  A61K9/0073 ,  A61K9/127 ,  A61K9/19 ,  A61K31/4745

    摘要： Provided herein is a method of treating primary lung cancer or metastatic cancer to the lung in an individual by delivering at least once to the respiratory tract of the individual via inhalation a nebulized liposomal aerosol comprising a dilauroylphosphatidylcholine liposome containing camptothecin or a derivative thereof in an amount sufficient to deliver a pharmacologically effective dose of the camptothecin or its derivative to treat the cancer. Also provided is a nebulized liposomal aerosol comprising the DLPC containing the camptothecin or its derivative and a method of making the liposome-drug comprising the aerosol.

    摘要翻译： 本文提供了一种通过吸入至少一次向个体的呼吸道递送一次雾化的脂质体气雾剂，其包含含有喜树碱或其衍生物的二月桂酰磷脂酰胆碱脂质体，其量为一种治疗个体的原发性肺癌或转移性癌症的方法 足以提供药理学有效剂量的喜树碱或其衍生物以治疗癌症。 还提供了包含含有喜树碱或其衍生物的DLPC的雾化脂质体气雾剂和制备包含气溶胶的脂质体药物的方法。