发明授权
- 专利标题： Carboxylic acid derivatives having fused rings
- 专利标题（中）： 具有稠环的羧酸衍生物
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申请号： US400980申请日： 1999-09-22
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公开(公告)号： US6110959A公开(公告)日： 2000-08-29
- 发明人: Katsuya Tagami , Hiroyuki Yoshimura , Mitsuo Nagai , Shigeki Hibi , Kouichi Kikuchi , Takashi Sato , Makoto Okita , Yasushi Okamoto , Yumiko Nagasaka , Naoki Kobayashi , Takayuki Hida , Kenji Tai , Naoki Tokuhara , Seiichi Kobayashi
- 申请人： Katsuya Tagami , Hiroyuki Yoshimura , Mitsuo Nagai , Shigeki Hibi , Kouichi Kikuchi , Takashi Sato , Makoto Okita , Yasushi Okamoto , Yumiko Nagasaka , Naoki Kobayashi , Takayuki Hida , Kenji Tai , Naoki Tokuhara , Seiichi Kobayashi
- 申请人地址： JPX Tokyo
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX8-88792 19960318; JPX8-210836 19960809; JPX8-345515 19961225
- 主分类号： C07C69/76
- IPC分类号： C07C69/76 ; C07C69/94 ; C07D207/32 ; C07D207/337 ; C07D307/54 ; C07D333/24 ; C07D405/04 ; C07D405/10 ; C07D405/14 ; C07D407/04 ; C07D409/04 ; C07D409/10 ; C07D409/14 ; A61K31/40 ; C07D207/30
摘要：
The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism.A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ##STR2## represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR3## [wherein R.sup.k (k: 1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR4## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.
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