发明授权
- 专利标题： Recombinant KAT enzyme and process for its preparation
- 专利标题（中）： 重组KAT酶及其制备方法
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申请号： US765889申请日： 1997-04-01
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公开(公告)号： US6136572A公开(公告)日： 2000-10-24
- 发明人: Luca Benatti , Jerome Breton , Carmela Speciale , Etsuo Okuno , Robert Schwarcz , Monica Mosca
- 申请人： Luca Benatti , Jerome Breton , Carmela Speciale , Etsuo Okuno , Robert Schwarcz , Monica Mosca
- 申请人地址： MD Baltimore ITX Milan
- 专利权人： University of Maryland at Baltimore,Pharmacia & Upjohn S.P.A.
- 当前专利权人： University of Maryland at Baltimore,Pharmacia & Upjohn S.P.A.
- 当前专利权人地址： MD Baltimore ITX Milan
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/47 ; A61K35/76 ; A61K38/45 ; A61K48/00 ; A61P25/28 ; C07D215/48 ; C12N5/10 ; C12N9/10 ; C12N15/54 ; C12Q1/68 ; C12R1/91 ; C12P17/00 ; C07H21/04
摘要：
Disclosed are isolated DNAs encoding a kynurenine aminotransferase selected from the group consisting of:(a) isolated DNA sequences which encode rat KAT;(b) an isolated DNA sequence which hybridizes to isolated DNA sequences of (a) above and which encodes a mammalian KAT enzyme; and(c) an isolated DNA sequence differing from the isolated DNA sequences of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a KAT enzyme.Vectors and host cells containing the same, oligonucleotide probes for identifying kynurenine aminotransferase, and isolated and purified kynurenine aminotransferase are also disclosed.
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