发明授权
US6147199A 2-deoxy-isoguanosines isoteric analogues and isoguanosine containing
oligonucleotides
失效
2-脱氧 - 异鸟嘌呤等同类似物和含有异鸟苷酸的寡核苷酸
- 专利标题： 2-deoxy-isoguanosines isoteric analogues and isoguanosine containing oligonucleotides
- 专利标题（中）： 2-脱氧 - 异鸟嘌呤等同类似物和含有异鸟苷酸的寡核苷酸
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申请号： US86910申请日： 1998-05-29
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公开(公告)号： US6147199A公开(公告)日： 2000-11-14
- 发明人: Frank Seela , Zigmunt Kasimierczuk , Klaus Muhlegger , Herbert Von Der Eltz
- 申请人： Frank Seela , Zigmunt Kasimierczuk , Klaus Muhlegger , Herbert Von Der Eltz
- 申请人地址： DEX Mannheim
- 专利权人： Boehringer Mannheim
- 当前专利权人： Boehringer Mannheim
- 当前专利权人地址： DEX Mannheim
- 优先权： DEX4140463 19911209
- 主分类号： C12P19/34
- IPC分类号： C12P19/34 ; A61K31/70 ; A61K31/7042 ; A61K31/7052 ; A61K31/7056 ; A61K31/7076 ; A61P31/12 ; C07H19/04 ; C07H19/052 ; C07H19/16 ; C07H19/20 ; C07H19/23 ; C07H21/00 ; C07H21/02 ; C07H21/04 ; C12Q1/68
摘要：
2'-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by photochemical irradiation. A further production process is the conversion of deoxyguanosines or guanosines by means of persilylation, reaction with ammonia and deamination in the 2 position. The compounds are suitable as pharmaceutical agents with antiviral efficacy.
公开/授权文献
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