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    2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis
    2.
    发明授权
    2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis 失效
    2-脱氧 - 异鸟嘌呤等位基因类似物和异鸟苷衍生物及其合成

    公开(公告)号：US06498241B1

    公开(公告)日：2002-12-24

    申请号：US09712454

    申请日：2000-11-13

    申请人： Frank Seela ,  Zigmunt Kasimierczuk ,  Klaus Mühlegger ,  Herbert Von Der Eltz

    发明人： Frank Seela ,  Zigmunt Kasimierczuk ,  Klaus Mühlegger ,  Herbert Von Der Eltz

    IPC分类号： C07H2104

    CPC分类号： C07H21/00 ,  C07H19/04

    摘要： 2′-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by photochemical irradiation. A further production process is the conversion of deoxyguanosines or guanosines by means of persilylation, reaction with ammonia and deamination in the 2 position. The compounds are suitable as pharmaceutical agents with antiviral efficacy.

    摘要翻译： 2-脱氧异鸟苷，式I-V的异构体类似物和异鸟嘌呤衍生物，其通过通式a或b的化合物生产并通过光化学辐射与芳酰基异氰酸酯或通式VI-IX的化合物反应。 进一步的生产过程是通过去硅藻土或鸟氨酸的转化，通过与二氨基反应和脱氨作用。 该化合物适合作为具有抗病毒功效的药剂。