发明授权
US6156528A Methods for using a phosphodiesterase in pharmaceutical screening to
identify compounds for treatment of neoplasia
失效
在药物筛选中使用磷酸二酯酶鉴定用于治疗瘤形成的化合物的方法
- 专利标题： Methods for using a phosphodiesterase in pharmaceutical screening to identify compounds for treatment of neoplasia
- 专利标题（中）： 在药物筛选中使用磷酸二酯酶鉴定用于治疗瘤形成的化合物的方法
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申请号： US216070申请日： 1998-12-19
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公开(公告)号： US6156528A公开(公告)日： 2000-12-05
- 发明人: Rifat Pamukcu , Gary A. Piazza
- 申请人： Rifat Pamukcu , Gary A. Piazza
- 申请人地址： PA Horsham
- 专利权人： Cell Pathways, Inc
- 当前专利权人： Cell Pathways, Inc
- 当前专利权人地址： PA Horsham
- 主分类号： C12Q1/26
- IPC分类号： C12Q1/26 ; C12Q1/44 ; C12Q1/533 ; G01N33/50
摘要：
This invention provides a method to identify compounds potentially useful for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
公开/授权文献
- US4874581A O.sub.2 /CO.sub.2 control in blood oxygenators 公开/授权日：1989-10-17
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