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1.Substituted condensation products of N-benzyl-3-indenylacentamides with heterocyclic aldehydes for neoplasia 失效
标题翻译: N-苄基-3-茚基胱胺与杂环醛用于瘤形成的缩合产物公开(公告)号:US06610854B2
公开(公告)日:2003-08-26
申请号:US10206687
申请日:2002-07-26
申请人: Gerhard J. Sperl , Paul Gross , Klaus Brendel , Gary A. Piazza , Rifat Pamukcu
发明人: Gerhard J. Sperl , Paul Gross , Klaus Brendel , Gary A. Piazza , Rifat Pamukcu
IPC分类号: C07D21324
CPC分类号: C07D239/26 , C07D213/56 , C07D215/14 , C07D237/08 , C07D241/12
摘要: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.
摘要翻译: N-苄基-3-茚基乙酰胺与杂环醛的取代缩合产物可用于诱导或促进凋亡和阻止不受控制的肿瘤细胞增殖,并且特别可用于阻滞和治疗肿瘤,包括癌前期和癌性病变。
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2.
公开(公告)号:US06486155B1
公开(公告)日:2002-11-26
申请号:US09198413
申请日:1998-11-24
申请人: Rifat Pamukcu , Gary A. Piazza
发明人: Rifat Pamukcu , Gary A. Piazza
IPC分类号: A61K31535
CPC分类号: A61K31/5377
摘要: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to isoquinoline derivatives.
摘要翻译: 一种通过将受影响的细胞暴露于异喹啉衍生物来抑制肿瘤形成,特别是癌性和癌前病变的方法。
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3.Substituted benzylidene indenyl formamides, acetamides and propionamides 失效
标题翻译: 取代的亚苄基茚基甲酰胺,乙酰胺和丙酰胺公开(公告)号:US06403831B1
公开(公告)日:2002-06-11
申请号:US09512866
申请日:2000-02-25
申请人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
发明人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
IPC分类号: C07C23542
CPC分类号: A61K31/4409 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/4402 , A61K31/4406
摘要: Substituted benzylidene indenyl formamides, acetamides and propionamides are useful in the treatment of precancerous lesions and neoplasms.
摘要翻译: 取代的亚苄基茚基甲酰胺,乙酰胺和丙酰胺可用于治疗癌前病变和肿瘤。
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4.Method for treating a patient with neoplasia by treatment with a paclitaxel derivative 失效
标题翻译: 用紫杉醇衍生物治疗患有瘤形成患者的方法公开(公告)号:US06235776B1
公开(公告)日:2001-05-22
申请号:US09190637
申请日:1998-11-12
申请人: Rifat Pamukcu , Kerstin B. Menander
发明人: Rifat Pamukcu , Kerstin B. Menander
IPC分类号: A61K31235
CPC分类号: A61K31/335 , A61K31/19 , A61K2300/00
摘要: This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with a paclitaxel derivative.
摘要翻译: 本发明提供了一种通过包括用紫杉醇衍生物治疗的辅助治疗来治疗瘤形成患者的方法。
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5.Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives 失效
标题翻译: 通过暴露于取代的2-芳基 - 苯并咪唑衍生物治疗瘤形成的方法公开(公告)号:US06211177B1
公开(公告)日:2001-04-03
申请号:US09200378
申请日:1998-11-24
申请人: Gerhard Sperl , Ulrich Ixkes , Rifat Pamukcu , Gary A. Piazza
发明人: Gerhard Sperl , Ulrich Ixkes , Rifat Pamukcu , Gary A. Piazza
IPC分类号: A61K3153
CPC分类号: A61K31/415 , A61K31/44 , A61K31/495 , A61K31/505 , A61K31/53
摘要: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions, by exposing the affected cells to substituted 2-aryl-benzimidazoles.
摘要翻译: 通过将受影响的细胞暴露于取代的2-芳基 - 苯并咪唑来抑制肿瘤形成,特别是癌性和癌前病变的方法。
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6.Method for treating a patient having precancerous lesion with 4-phenylphthalazine derivatives 失效
标题翻译: 用4-苯基酞嗪衍生物治疗患有癌前病变的患者的方法公开(公告)号:US06207666B1
公开(公告)日:2001-03-27
申请号:US09065662
申请日:1998-04-23
申请人: Gary Piazza , Rifat Pamukcu
发明人: Gary Piazza , Rifat Pamukcu
IPC分类号: A61K31495
CPC分类号: A61K31/502
摘要: Derivatives of 4-phenylphthalazine are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
摘要翻译: 4-苯基酞嗪衍生物可用于治疗患有癌前病变的患者。 这些化合物也可用于抑制肿瘤细胞的生长。
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7.Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives 失效
标题翻译: 用吡唑并吡哒嗪酮衍生物抑制肿瘤细胞的方法公开(公告)号:US6077842A
公开(公告)日:2000-06-20
申请号:US200376
申请日:1998-11-24
申请人: Rifat Pamukcu , Gary A. Piazza
发明人: Rifat Pamukcu , Gary A. Piazza
IPC分类号: A01N43/58
CPC分类号: A61K31/501
摘要: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to pyrazolopyridylpyridazinone derivatives.
摘要翻译: 通过将受影响的细胞暴露于吡唑并吡啶酮衍生物来抑制肿瘤形成,特别是癌和癌前病变的方法。
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公开(公告)号:US6063818A
公开(公告)日:2000-05-16
申请号:US868182
申请日:1997-06-03
申请人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
发明人: Gerhard Sperl , Paul Gross , Klaus Brendel , Rifat Pamukcu , Gary A. Piazza
IPC分类号: A61P35/00 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/505 , A61K31/535
CPC分类号: A61K31/4409 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/4402 , A61K31/4406
摘要: Substituted benzylidene indenyl formamides, acetamides and propionamides are useful in the treatment of precancerous lesions and neoplasms.
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9.Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives 失效
标题翻译: 用四环吡啶并[3,4-B]吲哚衍生物抑制肿瘤细胞的方法公开(公告)号:US6046199A
公开(公告)日:2000-04-04
申请号:US007098
申请日:1998-01-14
申请人: Rifat Pamukcu , Gary A. Piazza
发明人: Rifat Pamukcu , Gary A. Piazza
IPC分类号: A61K31/4985 , A61K31/495 , A61K31/50
CPC分类号: A61K31/4985
摘要: A method for inhibiting neoplastic, particularly cancerous and precancerous lesions by exposing the affected cells to pyrido[3,4b]indoles.
摘要翻译: 一种通过将受影响的细胞暴露于吡啶并[3,4b]吲哚来抑制肿瘤,特别是癌和癌前病变的方法。
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10.
公开(公告)号:US5776962A
公开(公告)日:1998-07-07
申请号:US481601
申请日:1995-06-07
申请人: Paul Gross , Gerhard Sperl , Rifat Pamukcu , Klaus Brendel
发明人: Paul Gross , Gerhard Sperl , Rifat Pamukcu , Klaus Brendel
IPC分类号: A61K31/365 , A61K31/40 , A61K31/407 , A61K31/4192 , A61K31/655 , A61K38/00 , A61P35/00 , C07D307/93 , C07D491/04 , C07D491/048 , C07D491/10 , C07K5/02 , A61K31/41 , C07D307/77
CPC分类号: C07D491/04 , A61K31/365 , A61K31/407 , A61K31/4192 , A61K31/655 , C07D307/93 , C07D491/10 , C07K5/0215 , A61K38/00
摘要: Substituted lactone compounds are useful in the treatment of precancerous lesions and neoplasms.
摘要翻译: 取代的内酯化合物可用于治疗癌前病变和肿瘤。
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