发明授权
US06858435B2 Method and system for peak parking in liquid chromatography-mass spectrometer (LC-MS) analysis
失效
液相色谱 - 质谱仪(LC-MS)分析中峰值停留的方法和系统
- 专利标题: Method and system for peak parking in liquid chromatography-mass spectrometer (LC-MS) analysis
- 专利标题(中): 液相色谱 - 质谱仪(LC-MS)分析中峰值停留的方法和系统
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申请号: US09970544申请日: 2001-10-03
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公开(公告)号: US06858435B2公开(公告)日: 2005-02-22
- 发明人: Jean-Pierre Chervet , Remco Swart , Johannes Petrus Cornelus Vissers
- 申请人: Jean-Pierre Chervet , Remco Swart , Johannes Petrus Cornelus Vissers
- 申请人地址: US CA Sunnyvale
- 专利权人: Dionex Corporation
- 当前专利权人: Dionex Corporation
- 当前专利权人地址: US CA Sunnyvale
- 代理机构: Dorsey & Whitney LLP
- 主分类号: G01N27/62
- IPC分类号: G01N27/62 ; G01N30/02 ; G01N30/26 ; G01N30/32 ; G01N30/34 ; G01N30/72 ; G01N30/78 ; G01N30/80 ; G01N30/84 ; G01N30/86 ; G01N30/88
摘要:
A reconfigurable multi-mode post-column analysis system improves resolution of liquid chromatography detection data by providing a parking or MS/MS detection mode in which flow of column eluent is substantially reduced to provide greater analysis time within a single eluting detection peak. A micro switching valve unit is reconfigurable between normal (MS) mode that passes column eluent directly to an MS unit, and a peak parking (or MS/MS) mode, in which normal mode column flow is interrupted, and the gradient halted, while more slowly flowing the detection peak of interest through the MS unit. A micro syringe pump contributes to the substantially lower MS/MS flow rate. A MS control unit controls micro switching valve valves to reconfigure between MS and MS/MS modes. After a detection peak, MS mode is reestablished, and the system primary pump returns to normal mode flow rate and gradient conditions. Mode changes can be carried out for each chromatogram detection peak.