公开(公告)号：US06858435B2

公开(公告)日：2005-02-22

申请号：US09970544

申请日：2001-10-03

申请人： Jean-Pierre Chervet ,  Remco Swart ,  Johannes Petrus Cornelus Vissers

发明人： Jean-Pierre Chervet ,  Remco Swart ,  Johannes Petrus Cornelus Vissers

IPC分类号： G01N27/62 ,  G01N30/02 ,  G01N30/26 ,  G01N30/32 ,  G01N30/34 ,  G01N30/72 ,  G01N30/78 ,  G01N30/80 ,  G01N30/84 ,  G01N30/86 ,  G01N30/88

CPC分类号： G01N30/84 ,  G01N30/32 ,  G01N30/7233 ,  G01N30/728 ,  G01N30/8631 ,  G01N2030/324 ,  G01N2030/8411 ,  Y10T436/24 ,  Y10T436/255

摘要： A reconfigurable multi-mode post-column analysis system improves resolution of liquid chromatography detection data by providing a parking or MS/MS detection mode in which flow of column eluent is substantially reduced to provide greater analysis time within a single eluting detection peak. A micro switching valve unit is reconfigurable between normal (MS) mode that passes column eluent directly to an MS unit, and a peak parking (or MS/MS) mode, in which normal mode column flow is interrupted, and the gradient halted, while more slowly flowing the detection peak of interest through the MS unit. A micro syringe pump contributes to the substantially lower MS/MS flow rate. A MS control unit controls micro switching valve valves to reconfigure between MS and MS/MS modes. After a detection peak, MS mode is reestablished, and the system primary pump returns to normal mode flow rate and gradient conditions. Mode changes can be carried out for each chromatogram detection peak.

摘要翻译： 可重新配置的多模式后柱分析系统通过提供停放或MS / MS检测模式来提高液相色谱检测数据的分辨率，其中柱洗脱液的流量被显着减少，以在单个洗脱检测峰内提供更大的分析时间。 微型切换阀单元可以在通过柱洗脱液直接送到MS单元的正常（MS）模式和在其中正常模式列流中断的峰值驻留（或MS / MS）模式下重新配置，并且梯度停止，同时 通过MS单元更慢地流过感兴趣的检测峰。 微注射泵有助于实质上较低的MS / MS流速。 MS控制单元控制微动开关阀阀门在MS和MS / MS模式之间进行重新配置。 检测峰值后，重新建立MS模式，系统主泵返回正常模式的流量和梯度条件。 可以对每个色谱图检测峰进行模式更改。

公开(公告)号：US07797989B2

公开(公告)日：2010-09-21

申请号：US11996069

申请日：2006-12-01

申请人： Remco Swart ,  Guillaume Tremintin

发明人： Remco Swart ,  Guillaume Tremintin

IPC分类号： G01N30/22 ,  G01N1/00

CPC分类号： G01N30/20 ,  G01N30/24 ,  G01N30/44 ,  G01N30/463 ,  G01N30/465 ,  G01N30/80 ,  G01N30/82 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/8804

摘要： A device for feeding samples to a separating device and for collecting sample fractions generated by means of the separating device, especially for high-performance liquid chromatography, with a first switch valve unit, which has at least eight ports and two switch positions. The device has a dosing device for feeding a sample to the switch valve unit, which is connected to a suction port of the first switch valve unit and which interacts with a removal and discharge device for the removal of a sample from at least one sample-holding container and for the discharge of each fraction into one of several fraction-holding containers, which is connected to a suction and discharge port of the first switch valve unit. The device uses a single switch valve unit configured in a new way to replace the function of two switch valve units, resulting in significantly simpler and cheaper construction.

摘要翻译： 用于将样品供给到分离装置并且用于收集通过分离装置产生的样品级分，特别是用于高效液相色谱的装置，其具有至少八个端口和两个开关位置的第一开关阀单元。 该装置具有用于将样品供给到切换阀单元的计量装置，该开关阀单元连接到第一开关阀单元的吸入口并且与去除和排出装置相互作用以从至少一个样品 - 并且将每个馏分排出到与第一开关阀单元的吸入口和排出口连接的几个馏分保持容器中的一个。 该设备使用单个开关阀单元，以新的方式配置以更换两个开关阀单元的功能，导致显着更简单和更便宜的结构。

公开(公告)号：US20080229810A1

公开(公告)日：2008-09-25

申请号：US11996069

申请日：2006-12-01

申请人： Remco Swart ,  Guillaume Tremintin

发明人： Remco Swart ,  Guillaume Tremintin

IPC分类号： G01N30/84

CPC分类号： G01N30/20 ,  G01N30/24 ,  G01N30/44 ,  G01N30/463 ,  G01N30/465 ,  G01N30/80 ,  G01N30/82 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/8804

摘要： The invention relates to a device for feeding samples to a separating device and for collecting sample fractions generated by means of the separating device, especially for high-performance liquid chromatography, with a first switch valve unit (201), which has at least eight ports (port numbers 1 to 8) and two switch positions, wherein, in a first switch position (1-2), exactly two adjacent ports are interconnected and wherein, in a second switch position (8-1), exactly those adjacent ports that are not interconnected in the first switch position are interconnected. The device has a dosing device (4) for feeding a sample to the switch valve unit (201), which is connected to a suction port (port number 1) of the first switch valve unit (201) and which interacts with a removal and discharge device (6) for the removal of a sample from at least one sample-holding container (7) and for the discharge of each fraction into one of several fraction-holding containers (12), which is connected to a suction and discharge port (port number 6) of the first switch valve unit (201). The ports of the first switch valve unit (201) are assigned so that in the first switch position (1-2), the suction port (port number 1) and the first sample reservoir port (port number 2), the solution feed port (port number 3) and the separating device transfer port (port number 4), the second sample reservoir port (port number 5) and the suction and discharge port (port number 6), and also the separating device transfer port (port number 7) and the waste port (port number 8) are interconnected and so that, in the second switch position (8-1), the first sample reservoir port (port number 2) and the solution feed port (port number 3), the separating device transfer port (port number 4) and the second sample reservoir port (port number 5), the suction and discharge port (port number 6) and the separating device transfer port (port number 7), and also the waste port (port number 8) and the suction port (port number 1) are interconnected.