公开(公告)号：US20240319151A1

公开(公告)日：2024-09-26

申请号：US18125781

申请日：2023-03-24

申请人： The Government of the United States of America, as represented by the Secretary of the Navy

发明人： Tyler J. Huffman ,  Robert Furstenberg ,  Christopher Breshike ,  R. Andrew McGill

IPC分类号： G01N30/74 ,  G01N30/72 ,  G01N30/78

CPC分类号： G01N30/74 ,  G01N30/722 ,  G01N30/78 ,  G01N2030/025 ,  G01N2030/746

摘要： The present invention provides a method of chemically analyzing complex mixtures using spectroscopy and chromatography by collecting spectroscopy data at multiple points along a chromatography column to identify and quantify analytes in minutes. Also disclosed is the related system for chromatography and in-column spectroscopy for chemical mixtures and a larger microfluidic system incorporating the chromatography and in-column spectroscopy system.

公开(公告)号：US12073924B2

公开(公告)日：2024-08-27

申请号：US17643128

申请日：2021-12-07

申请人： Genzyme Corporation

发明人： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock

IPC分类号： C12M3/00 ,  B01L3/00 ,  C07K1/16 ,  C12M1/00 ,  C12M1/12 ,  C12M1/36 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  G16C20/10 ,  B01D15/18 ,  G01N21/35 ,  G01N21/84 ,  G01N30/88

CPC分类号： G16C20/10 ,  C07K1/16 ,  C12M21/14 ,  C12M37/00 ,  C12M41/48 ,  C12M47/12 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  B01D15/1814 ,  B01D15/1871 ,  G01N2021/3595 ,  G01N2021/8416 ,  G01N2030/8813 ,  G01N2030/8886 ,  G01N2201/129

摘要： The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

公开(公告)号：US12066414B2

公开(公告)日：2024-08-20

申请号：US17748741

申请日：2022-05-19

申请人： Halliburton Energy Services, Inc.

发明人： Mathew Dennis Rowe

IPC分类号： G01N30/78 ,  G01N30/30 ,  G01N30/32 ,  G01N30/86 ,  G01N33/24 ,  G01N30/00 ,  G01N30/68 ,  G01N30/88

CPC分类号： G01N30/78 ,  G01N30/30 ,  G01N30/32 ,  G01N30/8665 ,  G01N33/241 ,  G01N2030/0095 ,  G01N2030/3007 ,  G01N2030/3053 ,  G01N2030/685 ,  G01N2030/8854

摘要： A modular gas detection system includes a primary gas chromatograph, a constant volume extractor positionable to provide a continuous fluid sample to the primary gas chromatograph, and a total hydrocarbon analyzer. The modular gas detection system also includes a processing device and a memory device including instructions executable by the processing device for causing the processing device to perform operations. The operations include adjusting a detection scheme of the primary gas chromatograph to update a detection range for the continuous fluid sample to detect different hydrocarbons within a single column. Further, the operations include controlling routing of the continuous fluid sample from the constant volume extractor to the primary gas chromatograph and the total hydrocarbon analyzer.

公开(公告)号：US20230408466A1

公开(公告)日：2023-12-21

申请号：US17748741

申请日：2022-05-19

申请人： Halliburton Energy Services, Inc.

发明人： Mathew Dennis Rowe

IPC分类号： G01N30/78 ,  G01N30/30 ,  G01N30/32 ,  G01N30/86 ,  G01N33/24

CPC分类号： G01N30/78 ,  G01N30/30 ,  G01N2030/0095 ,  G01N30/8665 ,  G01N33/241 ,  G01N30/32

摘要： A modular gas detection system includes a primary gas chromatograph, a constant volume extractor positionable to provide a continuous fluid sample to the primary gas chromatograph, and a total hydrocarbon analyzer. The modular gas detection system also includes a processing device and a memory device including instructions executable by the processing device for causing the processing device to perform operations. The operations include adjusting a detection scheme of the primary gas chromatograph to update a detection range for the continuous fluid sample to detect different hydrocarbons within a single column. Further, the operations include controlling routing of the continuous fluid sample from the constant volume extractor to the primary gas chromatograph and the total hydrocarbon analyzer.

公开(公告)号：US11681778B2

公开(公告)日：2023-06-20

申请号：US16322338

申请日：2016-08-03

申请人： SHIMADZU CORPORATION

发明人： Akira Noda

IPC分类号： G06F17/18 ,  G06N99/00 ,  G01N30/78 ,  G01N21/00 ,  G16B40/00 ,  G16B40/30 ,  G01N21/35 ,  G01N23/223 ,  G01N27/62 ,  G01N30/86 ,  G01N33/44 ,  G01N33/48 ,  G06N3/08

CPC分类号： G06F17/18 ,  G01N21/00 ,  G01N21/35 ,  G01N23/223 ,  G01N27/62 ,  G01N30/78 ,  G01N30/8675 ,  G01N33/442 ,  G01N33/48 ,  G06N3/08 ,  G06N99/00 ,  G16B40/00 ,  G16B40/30

摘要： An analysis data processing method for processing analysis data collected with an analyzing device for each of a plurality of samples, by applying an analytical technique using statistical machine learning to multidimensional analysis data formed by output values obtained from a plurality of channels of a multichannel detector provided in the analyzing device, the method including: acquiring a non-linear regression or non-linear discrimination function expressing analysis data obtained for known samples; calculating a contribution value of each of the output values obtained from the plurality of channels forming the analysis data of the known samples, to the acquired non-linear regression or non-linear discrimination function, based on a differential value of the non-linear regression function or non-linear discrimination function; and identifying one or more of the plurality of channels of the detector, which are to be used for processing analysis data obtained for an unknown sample, based on the contribution value.

公开(公告)号：US11016066B2

公开(公告)日：2021-05-25

申请号：US16310469

申请日：2017-06-12

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Tamara Mathea Elisabeth Nijsen ,  Johannes Weda

IPC分类号： G01N30/60 ,  G01N30/46 ,  G01N30/78 ,  G01N33/497 ,  G01N30/00 ,  G01N30/02 ,  G01N30/88 ,  G01N30/62

摘要： A gas analysis device suited for e.g. medical analysis of exhaled breath from a subject. A gas inlet receives a gas sample to a flow path for guiding the gas sample to two or more gas separators, e.g. gas chromatography columns, with respective molecule selectivity properties which are different. One or more detectors, each with a sensor, are arranged to generate respective responses to outputs from the two or more gas separators. A communication module generate output data in response to the respective responses from the one or more detectors, e.g. data indicative of selected molecules in the gas sample, e.g. data indicative of one or more diseases identified as a result of identified biomarkers in the gas sample. The device is suitable as a compact device, e.g. a handheld breath analysis device, since the use of a plurality of gas separators allows use of very molecule specific gas separators which can be implemented with a small size. E.g. a flow path with several parallel paths each comprising one or more gas separator may be used.

公开(公告)号：US10830740B2

公开(公告)日：2020-11-10

申请号：US13638676

申请日：2011-03-30

申请人： Klaus Gebauer

发明人： Klaus Gebauer

IPC分类号： G01N30/46 ,  B01D15/18 ,  G01N30/78 ,  G01N30/86

摘要： A method in a separation system including parallel fluid paths each having a separation module, includes providing a sensor of the same type in at least each of the parallel fluid paths except one: measuring a characteristic fluid property with at least one of the sensors in the parallel fluid paths; possibly measuring the same characteristic fluid property with a system sensor positioned in the outlet of the separation system; and comparing measured characteristic fluid properties to evaluate and/or qualify the performance of the separation system.

公开(公告)号：US10668406B2

公开(公告)日：2020-06-02

申请号：US15410958

申请日：2017-01-20

申请人： Waters Technologies Corporation

发明人： Amanda B. Dlugasch ,  Thomas E. Wheat ,  Dan Root ,  Jean-Michel Plankeele ,  Isabelle Francois ,  Edward R. Aig

IPC分类号： B01D15/18 ,  B01D15/24 ,  G01N30/78 ,  G01N30/16 ,  G01N30/34

摘要： The present disclosure relates to an enhanced multi-dimensional chromatography system and method using selectable At-Column Dilution to improve compatibility of the interface and transfer between the multiple dimensions. The use of At-Column Dilution (“ACD”) with multi-dimensional chromatography can provide greater retention of the diverted components on subsequent stationary phases, and increase the sensitivity and peak shape of the component(s) separated on subsequent dimensions.

公开(公告)号：US10605796B2

公开(公告)日：2020-03-31

申请号：US16200282

申请日：2018-11-26

申请人： TricornTech Taiwan

发明人： Tsung-Kuan A. Chou ,  Li-Peng Wang

IPC分类号： G01N1/00 ,  G01N33/00 ,  G01N30/78

摘要： Embodiments of a gas detector with a first gas sensor having a first gas specificity and a first response time and a second gas sensor having a second gas specificity and a second response time. The first gas specificity is different than the second gas specificity, the first response time is different than the second response time, or both the first gas specificity and the first response time are different than the second gas specificity and the second response time. A readout and analysis circuit is coupled to the first and second gas sensors to read and analyze data from the first and second gas sensors, and a control circuit is coupled to the readout and analysis circuit and to the first and second gas sensors to execute logic that operates the first gas sensor, the second gas sensor, or both the first and second gas sensors.

公开(公告)号：US20190265215A1

公开(公告)日：2019-08-29

申请号：US16286562

申请日：2019-02-26

申请人： Brigham Young University

发明人： Xiaofeng Xie ,  Luke T. Tolley ,  Paul B. Farnsworth ,  H. Dennis Tolley ,  Milton L. Lee

IPC分类号： G01N30/88 ,  G01N30/78

摘要： A system and method for separating the functions of a liquid chromatography (LC) system into physically separate systems that allow for a more versatile LC system, wherein an LC device provides column 50 a liquid solvent, a sample, and a pump and injector that pushes the sample in the solvent to an output port, and providing an attachable module containing a module input port, a column, a heater for the column, and at least one detector for on-column detection, then attaching the module to the LC device using a press-fit connection that enables the sample in the solvent to be pumped through the column to the at least one detector in order to separate, identify and quantify substances in the sample and transmit results from the at least one detector to the LC system for collection and analysis.