发明授权
- 专利标题： Synthesis of benzonitriles from substituted benzaldehyde
- 专利标题（中）： 从取代苯甲醛合成苯腈
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申请号： US10439286申请日： 2003-05-15
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公开(公告)号： US06875883B2公开(公告)日： 2005-04-05
- 发明人: Mukund S. Chorghade , Mukund K. Gurjar , Joseph Cherian
- 申请人： Mukund S. Chorghade , Mukund K. Gurjar , Joseph Cherian
- 申请人地址： US MA Cambridge
- 专利权人： Genzyme Corporation
- 当前专利权人： Genzyme Corporation
- 当前专利权人地址： US MA Cambridge
- 代理机构： Hamilton, Brook, Smith & Reynolds, PC
- 主分类号： C07D233/64
- IPC分类号： C07D233/64 ; A61K31/426 ; A61P7/02 ; A61P11/06 ; A61P29/00 ; A61P31/12 ; C07B53/00 ; C07B55/00 ; C07B61/00 ; C07C217/46 ; C07C227/18 ; C07C229/06 ; C07C229/42 ; C07C249/02 ; C07C253/00 ; C07C255/53 ; C07C255/54 ; C07C257/08 ; C07C319/02 ; C07C319/06 ; C07C319/12 ; C07C319/20 ; C07C323/00 ; C07C323/25 ; C07C323/35 ; C07C323/52 ; C07C323/56 ; C07C323/58 ; C07D213/55 ; C07D233/16 ; C07D237/02 ; C07D277/04 ; C07D277/08 ; C07D277/12 ; C07D277/14 ; C07D277/18 ; C07D277/56 ; C07D303/24 ; C07C253/12
摘要：
There is a significant demand for organic nitriles, based on their versatility in reactions. Compounds prepared from nitriles have properties including superoxide inhibition, ferrielectric liquid crystal dopant, antipicornaviral agents, anti-inflammatory agents, anti-asthma agents, and fibringoen antagonists. The present invention discloses a facile synthesis for 2,4-dihydroxybenzonitrile, and ethers and diethers thereof, from 2,4-dihydroxybenzaldehyde or 2,4-dimethoxybenzaldehyde. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, 2,4-dihydroxybenzonitrile is condensed with (S)-2-methylcysteine.
公开/授权文献
- US20030220504A1 Synthesis of benzonitriles from substituted benzaldehyde 公开/授权日：2003-11-27
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