发明授权
- 专利标题: Potassium channel inhibitors and method
- 专利标题(中): 钾通道抑制剂及方法
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申请号: US10823987申请日: 2004-04-14
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公开(公告)号: US06881753B2公开(公告)日: 2005-04-19
- 发明人: John Lloyd , Heather J. Finlay , Wayne Vaccaro , Karnail S. Atwal , Michael F. Gross , Kerry L. Spear
- 申请人: John Lloyd , Heather J. Finlay , Wayne Vaccaro , Karnail S. Atwal , Michael F. Gross , Kerry L. Spear
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Co.
- 当前专利权人: Bristol-Myers Squibb Co.
- 当前专利权人地址: US NJ Princeton
- 代理商 Deanna L. Baxam
- 主分类号: A61K31/277
- IPC分类号: A61K31/277 ; A61K31/352 ; A61K31/353 ; A61K31/381 ; A61K31/42 ; A61K31/429 ; A61K31/436 ; A61K31/472 ; A61K31/496 ; A61K31/506 ; A61P9/06 ; C07C303/40 ; C07C311/20 ; C07D215/42 ; C07D311/68 ; C07D401/12 ; C07D405/12 ; C07D405/14 ; C07D407/12 ; C07D409/12 ; C07D409/14 ; C07D413/04 ; C07D413/14 ; C07D417/12 ; C07D473/38 ; C07D491/04 ; C07D491/052 ; C07D493/04 ; C07D513/04 ; C07C279/28 ; A61K31/155 ; C07C279/18
摘要:
Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure: where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.
公开/授权文献
- US20040192710A1 Potassium channel inhibitors and method 公开/授权日:2004-09-30