Heterocyclic dihydropyrimidine compounds
    6.
    发明授权
    Heterocyclic dihydropyrimidine compounds 有权
    杂环二氢嘧啶化合物

    公开(公告)号:US06706720B2

    公开(公告)日:2004-03-16

    申请号:US09729731

    申请日:2000-12-05

    IPC分类号: C07D48704

    CPC分类号: C07D487/04 A61K31/519

    摘要: Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.

    摘要翻译: 可用作钾通道功能抑制剂的新型杂环二氢嘧啶化合物(特别是电压门控K +通道的Kv1亚族抑制剂,特别是与超快速激活延迟整流K +连接的抑制剂Kv1.5当前IKur ),使用这些化合物预防和治疗心律失常和IKur相关病症的方法,以及含有这些化合物的药物组合物。

    Heterocyclic dihydropyrimidine compounds
    7.
    发明授权
    Heterocyclic dihydropyrimidine compounds 有权
    杂环二氢嘧啶化合物

    公开(公告)号:US07541362B2

    公开(公告)日:2009-06-02

    申请号:US11634574

    申请日:2006-12-06

    IPC分类号: C07D401/06 A61K31/4025

    CPC分类号: C07D487/04 A61K31/519

    摘要: Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.

    摘要翻译: 可用作钾通道功能抑制剂的新型杂环二氢嘧啶化合物(特别是电压门控K +通道的Kv1亚族抑制剂,特别是与超快速激活延迟整流K +电流IKur连接的抑制剂Kv1.5),使用 预防和治疗心律失常和IKur相关病症的化合物,以及含有这些化合物的药物组合物。