发明授权
US06906094B2 1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase
失效
作为15-脂肪氧合酶抑制剂的1,2,4-三取代苯
- 专利标题： 1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase
- 专利标题（中）： 作为15-脂肪氧合酶抑制剂的1,2,4-三取代苯
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申请号： US10362104申请日： 2001-05-08
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公开(公告)号： US06906094B2公开(公告)日： 2005-06-14
- 发明人: Nicole Chantel Barvian , Patrick Michael O'Brien , William Chester Patt , Joseph Armand Picard , Drago Robert Sliskovic
- 申请人： Nicole Chantel Barvian , Patrick Michael O'Brien , William Chester Patt , Joseph Armand Picard , Drago Robert Sliskovic
- 申请人地址： US NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： US NJ Morris Plains
- 代理商 Charles W. Ashbrook; Eric J. Baude; Claude F. Purchase, Jr.
- 国际申请： PCT/US01/14795 WO 20010508
- 国际公布： WO01/96298 WO 20011220
- 主分类号： C07D295/08
- IPC分类号： C07D295/08 ; A61K31/27 ; A61K31/381 ; A61K31/40 ; A61K31/404 ; A61K31/5375 ; A61P9/00 ; A61P9/10 ; A61P11/06 ; A61P17/06 ; A61P19/02 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07C307/10 ; C07C311/48 ; C07C311/60 ; C07D207/08 ; C07D209/14 ; C07D209/48 ; C07D213/30 ; C07D295/088 ; C07D333/16 ; C07D209/04
摘要：
The present invention provides compounds of formula (I) wherein R, Z, Y, W, R5, V, and X are as defined in the description, and pharmaceutically acceptable salts thereof, which are useful for the treatment of diseases responsive to the inhibition of the enzyme 15-lipoxygenase. Thus, the compounds of formula (I) and their pharmaceutically acceptable salts are useful for treating diseases with an inflammatory component, including atherosclerosis, diseases involving chemotaxis of monocytes, inflammation, stroke, coronary artery disease, asthma, arthritis, colorectal cancer, and psoriasis.
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