发明授权
- 专利标题: DNA vaccine-PCV
- 专利标题(中): DNA疫苗-PCV
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申请号: US09586535申请日: 2000-05-31
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公开(公告)号: US06943152B1公开(公告)日: 2005-09-13
- 发明人: Francis Jean-Christophe Audonnet , Michel Bublot , Jennifer Maria Perez , Catherine Elisabeth Charreyre
- 申请人: Francis Jean-Christophe Audonnet , Michel Bublot , Jennifer Maria Perez , Catherine Elisabeth Charreyre
- 申请人地址: FR Lyons
- 专利权人: Merial
- 当前专利权人: Merial
- 当前专利权人地址: FR Lyons
- 代理机构: Frommer Lawrence & Haug LLP
- 代理商 Thomas J. Kowalski; Judy Jarecki-Black
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A01N63/00 ; A01N65/00 ; A61K9/00 ; A61K9/127 ; A61K39/12 ; A61K39/39 ; A61K48/00 ; A61P31/12 ; C07K14/01 ; C07K14/535 ; C12N15/74
摘要:
The invention relates to immunogenic preparations or vaccines comprising, on the one hand, a plasmid encoding and expressing a gene from PCV, in particular selected from the group consisting of ORF1 of PCV-2, ORF2 of PCV-2, ORF1 of PCV-1 and ORF2 of PCV-1, and, on the other hand, an element capable of increasing the immune response directed against the product of expression of the gene, which can be a carbomer, a porcine cytokine, e.g. GM-CSF or a cationic lipid of formula in which R1 is a saturated or unsaturated linear aliphatic radical having from 12 to 18 carbon atoms, R2 is another aliphatic radical comprising from 2 to 3 carbon atoms, andt X is an hydroxyle ou amine group. The cationic lipid can be DMRIE, possibly coupled with DOPE.
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