公开(公告)号：US07192594B2

公开(公告)日：2007-03-20

申请号：US10653849

申请日：2003-09-02

申请人： Deborah Haines ,  Gordon Allan ,  John Ellis ,  Brian Meehan ,  Edward Clark ,  Lori Hassard ,  John Harding ,  Catherine Elisabeth Charreyre ,  Gilles Emile Chappuis ,  Francis McNeilly ,  Li Wang ,  Lorne A. Babiuk ,  Andrew A. Potter ,  Philip Willson

发明人： Deborah Haines ,  Gordon Allan ,  John Ellis ,  Brian Meehan ,  Edward Clark ,  Lori Hassard ,  John Harding ,  Catherine Elisabeth Charreyre ,  Gilles Emile Chappuis ,  Francis McNeilly ,  Li Wang ,  Lorne A. Babiuk ,  Andrew A. Potter ,  Philip Willson

IPC分类号： A61K39/12

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/51 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10043 ,  C12Q1/701

摘要： The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.

摘要翻译： 新型PCVII病毒基因组的克隆描述为源自PCVII基因组的蛋白质的表达。 这些蛋白质可用于预防和治疗PCVII感染的疫苗组合物中，以及用于确定脊椎动物受试者中PCVII感染存在的诊断方法。 衍生自病毒基因组的多核苷酸可用作诊断引物和探针。

公开(公告)号：US20190070117A1

公开(公告)日：2019-03-07

申请号：US16182868

申请日：2018-11-07

申请人： Merial, Inc.

发明人： Noel Yves Henri Jean Genin

IPC分类号： A61K9/19 ,  F26B5/06 ,  C12N7/00 ,  A61K9/00 ,  A61K35/00 ,  A61K35/13

摘要： The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the present invention relates to methods for vitrifying biological preparations, including peptides, antigens, antibodies, cells, and the like.

公开(公告)号：US10213509B2

公开(公告)日：2019-02-26

申请号：US16125911

申请日：2018-09-10

申请人： Merial, Inc.

发明人： Noel Yves Henri Jean Genin

IPC分类号： A61K47/26 ,  A61K9/46 ,  A61K9/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/17 ,  A61K39/215 ,  A61K39/255 ,  A61K39/275 ,  A61K9/20

摘要： The present invention relates to novel stable compressed vaccine composition comprising at least one anhydrous antigenic component comprising a stabilizer susceptible to foaming when the composition is mixed with liquid diluent; and an effective amount of a sugar alcohol.

公开(公告)号：US10206928B2

公开(公告)日：2019-02-19

申请号：US15801109

申请日：2017-11-01

申请人： MERIAL INC.

发明人： Rolf Valter Attstrom ,  Hugo De Bruyn

IPC分类号： A61K31/5377 ,  A61K8/49 ,  A61Q11/00

摘要： Use of a compound having the formula (I) in a medicament for the prevention or treatment of a disease caused by oral bacteria in an animal wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180354917A1

公开(公告)日：2018-12-13

申请号：US15946642

申请日：2018-04-05

申请人： MERIAL INC.

发明人： Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC分类号： C07D261/04

摘要： The present invention provides crystalline forms of compound of formula (Ia) and processes of making the crystalline forms. Also provided are compositions comprising the crystalline forms and methods of use of the crystalline forms.

公开(公告)号：US20180304061A1

公开(公告)日：2018-10-25

申请号：US15769664

申请日：2016-10-21

申请人： MERIAL INC.

发明人： Christophe Sautereau

IPC分类号： A61M35/00 ,  B65D1/09

CPC分类号： A61M35/003 ,  A61J1/065 ,  A61M39/00 ,  B65D1/09

摘要： A storage and manual dispenser apparatus for dispensing a pharmaceutical liquid under atmospheric pressure. This apparatus retains the liquid in a controlled and stable environment during storage.

公开(公告)号：US10080798B2

公开(公告)日：2018-09-25

申请号：US15265545

申请日：2016-09-14

申请人： MERIAL, INC.

发明人： Frederic David ,  Zahia Hannas-Djebbara ,  Herve Poulet ,  Jules Maarten Minke

IPC分类号： A61K39/23 ,  C07K14/005 ,  C12N7/00 ,  A61K39/135 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61K39/23 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/525 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/575 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14323 ,  C12N2750/14334 ,  C12N2750/14371 ,  C12N2770/32123 ,  C12N2770/32134

摘要： The present invention encompasses canine parvovirus (CPV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing CPV virus-like particle (VLP), and a preparation method and a use thereof. The CPV VLPs provided by the invention are formed by the CPV VP2 protein. Further, the invention broadly encompasses vaccines comprising combinations of MLV and VLP, which are capable of overcoming MDA against a variety of pathogens, which infect a variety of different species.

公开(公告)号：US10071582B2

公开(公告)日：2018-09-11

申请号：US15498933

申请日：2015-10-30

申请人： MERIAL INC.

发明人： Andy Brehm ,  Julie Campbell ,  Ed Schindler ,  Dennis Jerome Freeman

IPC分类号： B41M5/24 ,  B41J3/407 ,  A61J1/18

CPC分类号： B41M5/24 ,  A61J1/18 ,  A61J2200/44 ,  B41J3/4075 ,  B41M5/26 ,  B41M5/267

摘要： This invention relates to an apparatus and method for applying writings and other markings to a frozen vial or ampoule, which is filled with biological material, and which is held at temperatures between about −70° C. and about −196° C. More particularly, the invention relates to a laser marking method that allows frozen vials to be labeled, while maintaining the integrity of the biological material contained therein.

公开(公告)号：US20180250382A1

公开(公告)日：2018-09-06

申请号：US15846735

申请日：2016-06-23

申请人： MERIAL INC.

发明人： Yu-Wei Chiang ,  David Cureton ,  Herve Poulet

IPC分类号： A61K39/145 ,  A61P31/16 ,  G01N33/569

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  A61P31/16 ,  C12N2760/16134 ,  G01N33/56983

摘要： The present invention relates to canine influenza virus strains, and vaccines and compositions. The present invention also relates to reagents and methods allowing their detection, methods of vaccination as well as methods of producing these reagents and vaccines.

公开(公告)号：US20180185336A1

公开(公告)日：2018-07-05

申请号：US15904798

申请日：2018-02-26

申请人： MERIAL INC.

发明人： Mark David Soll ,  Diane Larsen ,  Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska ,  Saijun Gong

IPC分类号： A61K31/42 ,  A61K31/365 ,  A61K31/4985 ,  A61K31/27 ,  A61K31/437 ,  A61K9/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/44 ,  A61K31/7048 ,  C07D261/04 ,  A61K45/06 ,  A23K20/00 ,  A61K47/42 ,  A61K31/325 ,  A01N43/80 ,  A61K31/194

摘要： This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.