- 专利标题： Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
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申请号： US10951992申请日： 2004-09-29
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公开(公告)号： US06951854B1公开(公告)日： 2005-10-04
- 发明人: Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
- 申请人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
- 申请人地址： US CA South San Francisco US IN Indianapolis
- 专利权人： Athena Neurosciences, Inc.,Eli Lilly and Company
- 当前专利权人： Athena Neurosciences, Inc.,Eli Lilly and Company
- 当前专利权人地址： US CA South San Francisco US IN Indianapolis
- 代理商 Robert D. Titus
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/4015 ; A61K31/445 ; A61K31/55 ; A61K38/04 ; A61K38/05 ; A61P25/28 ; C07D223/18 ; C07D471/04 ; C07D471/06 ; C07D471/08
摘要：
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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