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1.发明授权Compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis 有权用于抑制β-淀粉样蛋白肽释放和/或其合成的化合物公开(公告)号：US06207710B1
公开(公告)日：2001-03-27
申请号：US09164385
申请日：1998-09-30
申请人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu
发明人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu
IPC分类号： A01N3712
CPC分类号： A61K31/00 , A61K38/05 , A61K38/06 , C07K5/06078 , C07K5/06191
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物。
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2.发明授权Methods and compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis 失效用于抑制β-淀粉样蛋白肽释放和/或其合成的方法和化合物公开(公告)号：US06191166B1
公开(公告)日：2001-02-20
申请号：US08976289
申请日：1997-11-21
申请人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , John Varghese , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
发明人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , John Varghese , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
IPC分类号： A01N3712
CPC分类号： C07K5/06191 , A61K31/00 , A61K31/4015 , A61K31/405 , A61K31/445 , A61K31/47 , A61K38/05 , A61K38/06 , C07K5/06078
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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公开(公告)号：US5861425A
公开(公告)日：1999-01-19
申请号：US845053
申请日：1997-04-18
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/435 , A61K31/44 , A61K31/475 , A61P1/00 , A61P1/10 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D209/14 , C07D209/60 , C07D211/72 , C07D471/04
CPC分类号： C07D471/04 , C07D209/14 , C07D209/60
摘要： The present invention provides 3-ethanamine and 3-ethanamine related compounds which are useful intermediates and have beneficial central nervous system activity.
摘要翻译： 本发明提供了3-乙胺和3-乙胺相关的化合物，它们是有用的中间体并具有有益的中枢神经系统活性。
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公开(公告)号：US5538981A
公开(公告)日：1996-07-23
申请号：US438595
申请日：1995-05-10
IPC分类号： A61K31/475 , A61P25/00 , A61P43/00 , C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： The present invention provides novel tetrahydrobeta-carboline compounds and intermediates having useful central nervous system activity. The invention further provides formulations and methods for using the novel tetrahydrobeta-carboline compounds.
摘要翻译： 本发明提供了具有有用的中枢神经系统活性的新型四氢-咔啉化合物和中间体。 本发明还提供了使用新型四氢-咔啉化合物的制剂和方法。
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公开(公告)号：US5300645A
公开(公告)日：1994-04-05
申请号：US48392
申请日：1993-04-14
IPC分类号： A61K31/475 , A61P25/00 , A61P43/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a new Pictet-Spengler process useful for preparing tetrahydro-beta-carboline compounds.
摘要翻译： 本发明提供了可用于制备四氢-β-咔啉化合物的新型Pictet-Spengler方法。
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公开(公告)号：US06861558B2
公开(公告)日：2005-03-01
申请号：US10309569
申请日：2002-12-03
申请人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
发明人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
CPC分类号： C07K5/06191 , A61K31/00 , A61K31/4015 , A61K31/405 , A61K31/445 , A61K31/47 , A61K38/05 , A61K38/06 , C07K5/06078
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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公开(公告)号：US06635632B1
公开(公告)日：2003-10-21
申请号：US08996422
申请日：1997-12-22
申请人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
发明人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
IPC分类号： A61K3155
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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8.发明授权Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds 失效环烷基，内酰胺，内酯和相关化合物，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法公开(公告)号：US06632811B2
公开(公告)日：2003-10-14
申请号：US09915342
申请日：2001-07-27
申请人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
发明人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
IPC分类号： A61K3155
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物，以及预防和治疗阿尔茨海默病的方法，该药物组合物均为该药物组合物。
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公开(公告)号：US06544978B2
公开(公告)日：2003-04-08
申请号：US09915480
申请日：2001-07-27
申请人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
发明人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
IPC分类号： A61K3155
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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公开(公告)号：US06541466B2
公开(公告)日：2003-04-01
申请号：US09915362
申请日：2001-07-27
申请人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
发明人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
IPC分类号： A61K3155
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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