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公开(公告)号：US06509331B1
公开(公告)日：2003-01-21
申请号：US09337484
申请日：1999-06-21
申请人： James E. Audia , Richard C. Thompson , Stephen C. Wilkie , Thomas C. Britton , Warren J. Porter , George W. Huffman , Lee H. Latimer
发明人： James E. Audia , Richard C. Thompson , Stephen C. Wilkie , Thomas C. Britton , Warren J. Porter , George W. Huffman , Lee H. Latimer
IPC分类号： C07D48700
CPC分类号： C07D401/04 , A61K31/551 , A61K31/5513 , A61K31/553 , A61K31/655 , C07D221/22 , C07D223/18 , C07D243/12 , C07D243/14 , C07D243/24 , C07D409/04 , C07D409/12 , C07D417/04 , C07D471/06
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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2.发明授权Compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis 有权用于抑制β-淀粉样蛋白肽释放和/或其合成的化合物公开(公告)号：US06207710B1
公开(公告)日：2001-03-27
申请号：US09164385
申请日：1998-09-30
申请人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu
发明人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , Varghese John , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu
IPC分类号： A01N3712
CPC分类号： A61K31/00 , A61K38/05 , A61K38/06 , C07K5/06078 , C07K5/06191
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物。
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3.发明授权Methods and compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis 失效用于抑制β-淀粉样蛋白肽释放和/或其合成的方法和化合物公开(公告)号：US06191166B1
公开(公告)日：2001-02-20
申请号：US08976289
申请日：1997-11-21
申请人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , John Varghese , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
发明人： James E. Audia , Thomas C. Britton , James J. Droste , Beverly K. Folmer , George W. Huffman , John Varghese , Lee H. Latimer , Thomas E. Mabry , Jeffrey S. Nissen , Warren J. Porter , Jon K. Reel , Eugene D. Thorsett , Jay S. Tung , Jing Wu , Clark Norman Eid , William Leonard Scott
IPC分类号： A01N3712
CPC分类号： C07K5/06191 , A61K31/00 , A61K31/4015 , A61K31/405 , A61K31/445 , A61K31/47 , A61K38/05 , A61K38/06 , C07K5/06078
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译： 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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4.发明授权Method of foaming thermoplastic polymeric materials using tetrazole-containing heterocycles 失效使用含四唑的杂环使热塑性聚合材料发泡的方法
公开(公告)号：US4258138A
公开(公告)日：1981-03-24
申请号：US84966
申请日：1979-10-15
申请人： Thomas C. Britton
发明人： Thomas C. Britton
CPC分类号： C08J9/108
摘要： Method of foaming thermoplastic polymeric materials using as blowing agents polycyclic fused ring heterocycles containing the tetrazole moiety.
摘要翻译： 使用含有四唑部分的发泡剂多环稠环杂环使热塑性聚合物材料发泡的方法。
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5.发明授权Psychoactive 1,3,4-benzotriazepine-2-thiones and a method for treating central nervous system depression and anxiety 失效精神活性1,3,4-苯并三氮嘌呤-2-硫堇和一种治疗中枢神经系统抑郁和焦虑的方法
公开(公告)号：US4194000A
公开(公告)日：1980-03-18
申请号：US877064
申请日：1978-02-13
IPC分类号： C07D255/04 , C07D295/13 , C07D487/04 , C07D513/04 , A61K31/425 , A61K31/415
CPC分类号： C07D295/13 , C07D255/04 , C07D487/04 , C07D513/04
摘要： Novel 1,3,4-benzotriazepine-2-thiones and related tricyclic derivatives having central nervous system activity and a method of use for treating the symptoms of central nervous system depression and anxiety.
摘要翻译： 具有中枢神经系统活性的新型1,3,4-苯并三氮杂-二硫杂和相关三环衍生物以及用于治疗中枢神经系统抑郁和焦虑症状的方法。
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公开(公告)号：US4094871A
公开(公告)日：1978-06-13
申请号：US769126
申请日：1977-02-16
IPC分类号： C07D255/04 , C07D295/13 , C07D487/04 , C07D513/04 , C07D401/06 , C07D413/06
CPC分类号： C07D295/13 , C07D255/04 , C07D487/04 , C07D513/04
摘要： Novel 1,3,4-benzotriazepine-2-thiones and related tricyclic derivatives having central nervous system activity and a method of use for treating the symptoms of central nervous system depression and anxiety.
摘要翻译： 具有中枢神经系统活性的新型1,3,4-苯并三氮杂-二硫杂和相关三环衍生物以及用于治疗中枢神经系统抑郁和焦虑症状的方法。
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公开(公告)号：US06906056B2
公开(公告)日：2005-06-14
申请号：US10392332
申请日：2003-03-20
申请人： Richard C. Thompson , Stephen Wilkie , Douglas R. Stack , Eldon E. Vanmeter , Qing Shi , Thomas C. Britton , James E. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , Steven S. Henry , Stacey L. McDaniel , Russell D. Stucky , Warren J. Porter
发明人： Richard C. Thompson , Stephen Wilkie , Douglas R. Stack , Eldon E. Vanmeter , Qing Shi , Thomas C. Britton , James E. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , Steven S. Henry , Stacey L. McDaniel , Russell D. Stucky , Warren J. Porter
IPC分类号： A61K31/445 , A61K31/4706 , A61K31/501 , A61K31/55 , A61K38/00 , C07D401/12 , C07D403/12 , C07K5/097 , C07D267/02 , A61P25/28 , C07D223/12 , C07D487/00
CPC分类号： C07D401/12 , A61K38/00 , C07D403/12 , C07K5/0821 , C07K5/0823
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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公开(公告)号：US06667305B1
公开(公告)日：2003-12-23
申请号：US10336745
申请日：2003-01-06
申请人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
发明人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , R. Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , Cynthia L. Cwi , James J. Droste , Steven S. Henry , Stacey L. McDaniel , William Leonard Scott , Russell D. Stucky , Warren J. Porter
IPC分类号： A61P2528
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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公开(公告)号：US06579867B2
公开(公告)日：2003-06-17
申请号：US09915379
申请日：2001-07-27
申请人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , James J. Droste , Steven S. Henry , Stacey L. McDaniel , Russell D. Stucky , Warren J. Porter
发明人： Jing Wu , Jay S. Tung , Eugene D. Thorsett , Michael A. Pleiss , Jeffrey S. Nissen , Jeffrey Neitz , Lee H. Latimer , Varghese John , Stephen Freedman , Thomas C. Britton , James A. Audia , Jon K. Reel , Thomas E. Mabry , Bruce A. Dressman , James J. Droste , Steven S. Henry , Stacey L. McDaniel , Russell D. Stucky , Warren J. Porter
IPC分类号： A61K3155
CPC分类号： C07D471/04 , A61K31/40 , A61K31/4015 , A61K31/445 , A61K31/5513 , A61K38/05 , C07C237/22 , C07C2603/32 , C07D223/18 , C07D307/33 , C07D311/76 , C07D471/06 , C07D471/08
摘要： Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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10.发明授权Method for preparing 6-phenyl-triazolo or imidazolo-(1,3,4)-benzotriazepines and the novel intermediates used therewith 失效制备6-苯基 - 三唑并（咪唑并 - （1,3,4） - 苯并三氮杂的方法及其使用的新型中间体
公开(公告)号：US4189588A
公开(公告)日：1980-02-19
申请号：US951912
申请日：1978-10-16
IPC分类号： C07D255/04 , C07D295/13 , C07D487/04
CPC分类号： C07D295/13 , C07D255/04 , C07D487/04
摘要： Novel triazolo- or imidazo-benzotriazepines are prepared from 1,3,4-benzotriazepine-2-thiones which in turn are prepared from a 2-aminobenzophenone.
摘要翻译： 由1,3,4-苯并三氮杂-2-噻吩制备新的三唑并 - 咪唑并 - 苯并三氮杂，其又由2-氨基二苯甲酮制备。
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