Invention Grant
- Patent Title: In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
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Application No.: US10326190Application Date: 2002-12-20
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Publication No.: US07101546B2Publication Date: 2006-09-05
- Inventor: Wen-Ghih Tsang , Tianli Zheng , Yanping Wang
- Applicant: Wen-Ghih Tsang , Tianli Zheng , Yanping Wang
- Applicant Address: US CA Santa Monica
- Assignee: AmCyte, Inc.
- Current Assignee: AmCyte, Inc.
- Current Assignee Address: US CA Santa Monica
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: A61K35/39
- IPC: A61K35/39 ; C12N5/06 ; C12N5/00 ; C12N5/08

Abstract:
This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be matured in situ into a stable cell line that produces insulin in response to glucose. These cells are advantageous in that they are both expandable and stable in culture. This invention avoids the step of culturing the intermediate stage stem cells into later stage pancreatic cells.
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