公开(公告)号：US20130053304A1

公开(公告)日：2013-02-28

申请号：US13643840

申请日：2011-04-29

Applicant: Yinxiang Wang ,  Fenlai Tan ,  Shaojing Hu ,  Xiangdong Zhao ,  Cunbo Ma ,  Yanping Wang ,  Xiaoyan Shen ,  Lieming Ding ,  Yunyan Hu ,  Hong Cao ,  Wei Long

Inventor： Yinxiang Wang ,  Fenlai Tan ,  Shaojing Hu ,  Xiangdong Zhao ,  Cunbo Ma ,  Yanping Wang ,  Xiaoyan Shen ,  Lieming Ding ,  Yunyan Hu ,  Hong Cao ,  Wei Long

IPC: A61K38/26 ,  A61P3/10 ,  A61P3/08 ,  A61P3/04 ,  A61P9/12 ,  A61P1/04 ,  A61P25/00 ,  A61P9/10 ,  A61P9/00 ,  A61P7/02 ,  A61P1/00 ,  C07K14/605 ,  A61P3/06

CPC classification number: C07K14/605 ,  A61K38/00

Abstract: Provided is a glucagon-like peptide-1 (GLP-1) analogue shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analogue has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analogue is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analogue in conquering blood sugar.

Abstract translation: 本发明提供如下式所示的胰高血糖素样肽-1（GLP-1）类似物，其中X选自甘氨酸和甘氨酰胺。 GLP-1类似物相对于序列GLP-1具有位置8的非蛋白原性氨基酸残基，并且用包含两个酸性基团的部分酰化至位置26的赖氨酸残基。GLP-1类似物对 二肽基肽酶IV，以使体内延长半衰期。 还提供了GLP-1类似物在征服血糖中的用途。

公开(公告)号：US20120202463A1

公开(公告)日：2012-08-09

申请号：US13501299

申请日：2010-08-25

Applicant: Yanping Wang ,  Yanqiang Zuo ,  Hu Feng

Inventor： Yanping Wang ,  Yanqiang Zuo ,  Hu Feng

IPC: H04W12/08

CPC classification number: H04W48/20

Abstract: A cell locking method for a mobile terminal and a mobile terminal capable of locking a cell are disclosed in the present invention. The method includes: the mobile terminal acquiring a system identification (SID), a network identification (NID), a base station identifier (BASE ID) and a pseudo-random number (PN) of a current cell; judging whether the SID, NID, BASE ID and PN are already stored in a database of the mobile terminal, if yes, then setting the mobile terminal to a normal status; judging whether the SID, the NID, and the PN are already stored in the database of the mobile terminal and the database is not full, or whether the BASE ID and PN are already stored in the database of the mobile terminal, if yes, then transferring to D; and D. writing the SID, NID, BASE ID and PN into the database of the mobile terminal.

Abstract translation: 在本发明中公开了一种用于移动终端和能够锁定小区的移动终端的小区锁定方法。 该方法包括：移动终端获取当前小区的系统标识（SID），网络标识（NID），基站标识符（BASE ID）和伪随机数（PN）; 判断SID，NID，BASE ID和PN是否已经存储在移动终端的数据库中，如果是，则将移动终端设置为正常状态; 判断SID，NID和PN是否已经存储在移动终端的数据库中，并且数据库未满，或者BASE ID和PN是否已经存储在移动终端的数据库中，如果是，则 转移到D; 以及D.将SID，NID，BASE ID和PN写入到移动终端的数据库中。

公开(公告)号：US20070193409A2

公开(公告)日：2007-08-23

申请号：US11356723

申请日：2006-02-17

Applicant: Jilin He ,  Luntao Pan ,  Aiguo Zheng ,  Yuewei Cheng ,  Yuezhong Ma ,  Hongdong Liu ,  Guoqi Yang ,  Chunxiang Wang ,  Yanping Wang ,  Shiping Zheng

Inventor： Jilin He ,  Luntao Pan ,  Aiguo Zheng ,  Yuewei Cheng ,  Yuezhong Ma ,  Hongdong Liu ,  Guoqi Yang ,  Chunxiang Wang ,  Yanping Wang ,  Shiping Zheng

IPC: B22F9/04

CPC classification number: B22F1/0096 ,  B22F2998/00 ,  B22F2998/10 ,  B22F2999/00 ,  H01G9/0525 ,  B22F9/22 ,  B22F9/023 ,  B22F1/0014 ,  B22F1/0048 ,  B22F1/0055 ,  B22F1/0085 ,  B22F2201/20 ,  B22F9/04 ,  B22F2009/042

Abstract: A method for spherically granulating and agglomerating metal particles such as tantalum and/or niobium powders is described in the present invention, which includes the steps of: a). comminuting the metal particles to form fine particles having D50 less than 50 μm; b). granulating the comminuted metal particles comprising volatile liquid, for example, tantalum and/or niobium particles comprising volatile liquid, to form wet spherical particles; c). still drying the wet spherical particles and removing volatile liquid to form flowable pre-agglomerated particles with increased bulk density; d). heat treating the pre-agglomerated particles; e). screening the heat treated powder to obtain the flowable agglomerated particles. The present invention provides a flowable spherical agglomerated metal particles, and especially tantalum and/or niobium particles having improved properties. The present agglomerated tantalum powder have a flow rate of at least about 2.0 g/sec, a BET surface area of from about 0.2 to about 6.0 m2/g, a FSSS of at least 1.0 μm, a Scott bulk density of from about 1.2 g/cm3 to about 5.5 g/cm3. The present agglomerated niobium powder have a flow rate of at least about 1.0 g/sec, a BET surface area of from about 0.5 to about 8.0 m2/g, a FSSS of at least 1.0 μm, a Scott bulk density of from about 0.7 g/cm3 to about 3.5 g/cm3. Said tantalum and/or niobium metal particles have improved pore size distribution of the sintered anodes and increased pellet crush strength. The present invention further provides an electrolytic capacitor anodes made from the tantalum and/or niobium particles according to the present invention having a capacitance of from about 5,000 μFV/g to about 300,000 μFV/g.

公开(公告)号：US09238637B2

公开(公告)日：2016-01-19

申请号：US14166203

申请日：2012-07-30

Applicant: Xinshan Kang ,  Wei Long ,  Fei Wang ,  Cunbo Ma ,  Liufeng Zhou ,  Yunyan Hu ,  Yanping Wang ,  Hong Cao ,  Yinxiang Wang ,  Fenlai Tan

Inventor： Xinshan Kang ,  Wei Long ,  Fei Wang ,  Cunbo Ma ,  Liufeng Zhou ,  Yunyan Hu ,  Yanping Wang ,  Hong Cao ,  Yinxiang Wang ,  Fenlai Tan

IPC: A01N43/16 ,  C07D311/56

CPC classification number: C07D311/56

Abstract: The polymorphic forms of the compound of Formula I, the preparation thereof including the preparation of the intermediates, the pharmaceutical compositions thereof and the uses of a polymorph above in the manufacture of medicaments for treating a disease, a disorder or a condition are disclosed.

Abstract translation: 公开了式I化合物的多晶型物，其制备方法，包括制备中间体，其药物组合物，以及上述多晶型物在制备用于治疗疾病，病症或病症的药物中的用途。

公开(公告)号：US20130225587A1

公开(公告)日：2013-08-29

申请号：US13884470

申请日：2011-11-09

Applicant: Xinshan Kang ,  Wei Long ,  Cunbo Ma ,  Yanping Wang ,  Xiaoyan Shen ,  Yunyan Hu ,  Fenlai Tan ,  Yinxiang Wang

Inventor： Xinshan Kang ,  Wei Long ,  Cunbo Ma ,  Yanping Wang ,  Xiaoyan Shen ,  Yunyan Hu ,  Fenlai Tan ,  Yinxiang Wang

IPC: C07D417/14 ,  C07D405/14 ,  C07D233/88 ,  C07D417/12 ,  C07D241/20 ,  C07D285/08 ,  C07D401/14 ,  C07D405/12

CPC classification number: C07D417/14 ,  C07D213/74 ,  C07D213/80 ,  C07D213/803 ,  C07D233/88 ,  C07D241/20 ,  C07D277/42 ,  C07D285/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12

Abstract: The compound of Formula (I), pharmaceutically acceptable salts thereof, solvates thereof, chelates thereof, non-covalent complexes thereof or produgs of compounds mentioned above or the mixture of any form above mentioned are provided. The use of the compounds in manufacturing a medicament for the treatment and/or prevention of diabetes, obesity and related disorders.

Abstract translation: 提供式（I）的化合物，其药学上可接受的盐，其溶剂化物，其螯合物，其非共价络合物或上述化合物的产物或上述任何形式的混合物。 化合物在制备用于治疗和/或预防糖尿病，肥胖症和相关疾病的药物中的用途。

公开(公告)号：US20130203672A1

公开(公告)日：2013-08-08

申请号：US13698819

申请日：2010-05-17

Applicant: Shaojing Hu ,  Fenlai Tan ,  Yanping Wang ,  Cunbo Ma ,  Yunyan Hu ,  Hong Cao ,  Xiangdong Zhao ,  Wei Long ,  Yinxiang Wang ,  Lieming Ding

Inventor： Shaojing Hu ,  Fenlai Tan ,  Yanping Wang ,  Cunbo Ma ,  Yunyan Hu ,  Hong Cao ,  Xiangdong Zhao ,  Wei Long ,  Yinxiang Wang ,  Lieming Ding

IPC: C07K14/605

CPC classification number: C07K14/605 ,  A61K9/0019 ,  A61K38/00

Abstract: The present invention relates to novel analogs of glucagon like peptide and compositions that are useful for up-regulating insulin expression in mammals and for treating diabetes. In particular, these peptide derivatives have a peptide mimic linker and provides long duration of action for the treatment of diabetes and other insulinotropic peptide related diseases, gastrointestinal function and activities associated with glucagon levels.

Abstract translation: 本发明涉及胰高血糖素样肽的新型类似物和可用于上调哺乳动物胰岛素表达和治疗糖尿病的组合物。 特别地，这些肽衍生物具有肽模拟接头并且提供用于治疗糖尿病和其它促胰岛素肽相关疾病，胃肠功能和与胰高血糖素水平相关的活性的长期作用。

公开(公告)号：US20120172399A1

公开(公告)日：2012-07-05

申请号：US13384097

申请日：2010-07-14

Applicant: Xinshan Kang ,  Wei Long ,  Cunbo Ma ,  Yanping Wang ,  Hong Cao ,  Yinxiang Wang ,  Fenlai Tan ,  Yunyan Hu

Inventor： Xinshan Kang ,  Wei Long ,  Cunbo Ma ,  Yanping Wang ,  Hong Cao ,  Yinxiang Wang ,  Fenlai Tan ,  Yunyan Hu

IPC: A61K31/4433 ,  C07D405/10 ,  A61K31/37 ,  A61P3/10 ,  A61P35/00 ,  A61P7/00 ,  A61P7/06 ,  A61P17/02 ,  A61P37/06 ,  A61P9/12 ,  A61P29/00 ,  C07D311/56 ,  A61P9/10

CPC classification number: A61K31/37 ,  C07D311/56 ,  C07D405/04

Abstract: This invention relates to new compounds that can serve as hypoxia mimetics. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one of these compounds.

Abstract translation: 本发明涉及可用作缺氧模拟物的新化合物。 本发明还涉及通过向受试者施用这些化合物中的至少一种来提高受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。

公开(公告)号：US07305446B2

公开(公告)日：2007-12-04

申请号：US10699976

申请日：2003-11-03

Applicant: Hemanta K. Dutta ,  Seeta Hariharan ,  Sridhar Rao ,  Yanping Wang

Inventor： Hemanta K. Dutta ,  Seeta Hariharan ,  Sridhar Rao ,  Yanping Wang

IPC: G06F15/16

CPC classification number: G06F9/546

Abstract: An efficient method for performing state based ingress packet selection for a packet processing system in a network processor is disclosed. With this method, each set of message classes is associated with a state of an application, and each set of message classes is assigned to a semaphore. The application blocks one of the semaphores based on its current state. When a message is received, and the message belongs to a class assigned to the blocked semaphore, the blocked semaphore is signaled. The blocked semaphore then wakes the application. In this manner, when the application is awakened, it is guaranteed to find a message that it is interested in processing in its current state, resulting in greater efficiency in the processing of ingress messages.

Abstract translation: 公开了一种用于对网络处理器中的分组处理系统执行基于状态的入口分组选择的有效方法。 使用该方法，每组消息类与应用的状态相关联，并且将每组消息类分配给信号量。 应用程序根据其当前状态阻止其中一个信号量。 当接收到消息，并且消息属于分配给阻塞信号量的类时，将发出被阻塞的信号量。 封锁的信号量然后唤醒应用程序。 以这种方式，当应用被唤醒时，保证在其当前状态中找到对其进行处理感兴趣的消息，导致进入消息处理的效率更高。

公开(公告)号：US20070068341A1

公开(公告)日：2007-03-29

申请号：US11356723

申请日：2006-02-17

Applicant: Yuewei Cheng ,  Yuezhong Ma ,  Hongdong Liu ,  Guoqi Yang ,  Chunxiang Wang ,  Yanping Wang ,  Shiping Zheng

Inventor： Yuewei Cheng ,  Yuezhong Ma ,  Hongdong Liu ,  Guoqi Yang ,  Chunxiang Wang ,  Yanping Wang ,  Shiping Zheng

IPC: B22F9/04

CPC classification number: B22F1/0096 ,  B22F2998/00 ,  B22F2998/10 ,  B22F2999/00 ,  H01G9/0525 ,  B22F9/22 ,  B22F9/023 ,  B22F1/0014 ,  B22F1/0048 ,  B22F1/0055 ,  B22F1/0085 ,  B22F2201/20 ,  B22F9/04 ,  B22F2009/042

Abstract: A method for spherically granulating and agglomerating metal particles such as tantalum and/or niobium powders is described in the present invention, which includes the steps of: a). comminuting the metal particles to form fine particles having D50 less than 50 μm; b). granulating the comminuted metal particles comprising volatile liquid, for example, tantalum and/or niobium particles comprising volatile liquid, to form wet spherical particles; c). still drying the wet spherical particles and removing volatile liquid to form flowable pre-agglomerated particles with increased bulk density; d). heat treating the pre-agglomerated particles; e). screening the heat treated powder to obtain the flowable agglomerated particles. The present invention provides a flowable spherical agglomerated metal particles, and especially tantalum and/or niobium particles having improved properties. The present agglomerated tantalum powder have a flow rate of at least about 2.0 g/sec, a BET surface area of from about 0.2 to about 6.0 m2/g, a FSSS of at least 1.0 μm, a Scott bulk density of from about 1.2 g/cm3 to about 5.5 g/cm3. The present agglomerated niobium powder have a flow rate of at least about 1.0 g/sec, a BET surface area of from about 0.5 to about 8.0 m2/g, a FSSS of at least 1.0 μm, a Scott bulk density of from about 0.7 g/cm3 to about 3.5 g/cm3. Said tantalum and/or niobium metal particles have improved pore size distribution of the sintered anodes and increased pellet crush strength. The present invention further provides an electrolytic capacitor anodes made from the tantalum and/or niobium particles according to the present invention having a capacitance of from about 5,000 μFV/g to about 300,000 μFV/g.

公开(公告)号：US07101546B2

公开(公告)日：2006-09-05

申请号：US10326190

申请日：2002-12-20

Applicant: Wen-Ghih Tsang ,  Tianli Zheng ,  Yanping Wang

Inventor： Wen-Ghih Tsang ,  Tianli Zheng ,  Yanping Wang

IPC: A61K35/39 ,  C12N5/06 ,  C12N5/00 ,  C12N5/08

CPC classification number: A61L27/3804 ,  A61K9/1652 ,  A61K35/12 ,  A61L27/3834 ,  A61L27/3895 ,  C12N5/0676 ,  C12N5/0677

Abstract: This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be matured in situ into a stable cell line that produces insulin in response to glucose. These cells are advantageous in that they are both expandable and stable in culture. This invention avoids the step of culturing the intermediate stage stem cells into later stage pancreatic cells.